ABSTRACT:
Plant gums and mucilage widely have been used in Pharmaceuticals and in other various industries due to their abundance in nature and low cost. In view of importance of binders in pharmaceuticals for the manufacture of tablets and capsules, gum isolated from the seeds of Cassia roxburghii Linn, and the stem of Moringa oleifera has been evaluated for their binding properties in the formulation of Paracetamol tablet containing 2%, 4% and 6% binding concentration. The binding properties of both gums were evaluated in relation to conventional binder like guar gum, gelatin, Sod.CMC at different parameter like percentage of fines, tablet hardness, disintegration time, dissolution and friability and found that 2% binding concentration of both gum shows superior binding properties when compared to the other binders. Increase in concentration of filtered and defatted C. roxburghii gum, M. oleifera gum from 2% to 6%; decrease the percentage of fine, increase the hardness, increase the disintegration time, decrease the percentage of friability and decrease % cumulative release. Hence Paracetamol tablets were formulated using combination of (1% C.rox+1%M.oleifera) binding concentration and evaluated. The binder-excipients interaction study was also carried out by using FTIR i.e. by KBr pellet method which showed that C. Roxburghii gum, M.oleifera gum is compatible with drug and all excipients in the formulation. Results indicates that Paracetamol tablets prepared with 2 % ( 1% C. roxburghii + 1% M. oleifera) of mucilage were found to be ideal for the preparation of uncoated tablet formulation when high mechanical strength is more essential. Hence these gums shows better tabletting characteristics have high potentials for the substitution for more expensive binders.