Yarnykh T. G., Kotvitska A. A., Tykhonov A. I., Rukhmakova O. A.
Yarnykh T. G.1, Kotvitska A. A.2, Tykhonov A. I.3, Rukhmakova O. A.4*
1Doctor of Pharmacy, Professor, Head of Drugs Technology Department, NUPh, Ukraine.
2Doctor of Pharmacy, Professor, Rector of NUPh, Ukraine.
3Doctor of Pharmacy, Professor, Professor of Cosmetology and Aromology Department, NUPh, Ukraine.
4Doctor of Pharmacy, Associate Professor, Associate Professor of Drugs Technology Department, NUPh, Ukraine.
Volume - 13,
Issue - 7,
Year - 2020
The objective of the work – is to study and analyze causes of incompatibilities, their types and ways of overcoming in extemporaneous prescriptions based on data from literary sources. In the work, the retrospective, logical, and analytical research methods have been used to analyze the data of special literature. Based on the data of modern scientific literature, causes of pharmaceutical incompatibilities, their types and major ways of overcoming in extemporaneous prescriptions have been studied and analyzed. The given information of the problem of pharmaceutical incompatibilities, in our opinion, will increase the professional knowledge of pharmacists about the physical phenomena and chemical interactions that may occur in dosage forms, types of pharmacological incompatibilities and will guide them in practical activities in preparation of extemporaneous medicines in different dosage forms.
Cite this article:
Yarnykh T. G., Kotvitska A. A., Tykhonov A. I., Rukhmakova O. A. Pharmaceutical Incompatibilities: Causes, Types and Major ways of Overcoming in Extemporaneous Medicinal forms. Research J. Pharm. and Tech. 2020; 13(7): 3459-3465. doi: 10.5958/0974-360X.2020.00614.9
Yarnykh T. G., Kotvitska A. A., Tykhonov A. I., Rukhmakova O. A. Pharmaceutical Incompatibilities: Causes, Types and Major ways of Overcoming in Extemporaneous Medicinal forms. Research J. Pharm. and Tech. 2020; 13(7): 3459-3465. doi: 10.5958/0974-360X.2020.00614.9 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2020-13-7-74
1. Bentley J, Heard J, Collins G, Chung C. Mixing medicines: how to ensure patient safety. Pharmac J. 2015;294(7859).
2. Dash A, Singh S, Tolman J. Pharmaceutics: Basic Principles and Application to Pharmacy Practice. USA: Academic Press; 2013. p. 392.
3. Elliott M, Liu Y. The nine rights of medication administration: an overview. Br J Nurs. 2010;19(5):300-5.
4. FIP. Reference guide on Good Pharmacy Practice in community and hospital settings. First edition, 2009. – https://www.fip.org/www/uploads/database_file.php?id=331&table_id=
5. Joint FIP/WHO guidelines on good pharmacy practice. WHO Technical Report Series, No. 961, 2011. Geneva: WHO, 2011. http://apps.who.int/medicinedocs/en/m/abstract/Js18676en/
6. Kanji S, Lam J, Johanson C, et al. Systematic review of compatibility of commonly used medications administered by continuous infusion. Crit Care Med. 2010;38(9):1890-8.
7. Klopotowska JE, Kuiper R, van Kan HJ, et al. On-ward participation of a hospital pharmacist in a Dutch intensive care unit reduces errors and related harm. Crit Care. 2010;14(5):R174.
8. Newton D. Drug incompatibility chemistry. Am J Health Syst Pharm. 2009;66(4):348-57. Erratum in Am J Health Syst Pharm. 2009;66(16):1431.
9. Perez M, Décaudin B, Foinard A, et al. Compatibility of medications during multi-infusion therapy: a controlled study on a infusion device. Anaesth Crit Care Pain Med. 2015;34(2):83-8.
10. Pharmaceutical Stability. USP Pharmacists’ Pharmacopeia. 2nd ed. Rockville: The United State Pharmacopeia; 2008. p. 922-3.
11. Qiu Y, Chen Y, Zhang GG, Yu L, Mantri RV. Developing Solid Oral Dosage Forms: Pharmaceutical Theory and Practice. 2nd ed. New York: Academic Press; 2016. p. 1176.
12. Rothschild JM, Churchill W, Erickson A, et al. Medication errors recovered by emergency department pharmacists. Ann Emerg Med. 2010;55(6):513-21.
13. Stability Considerations in Dispensing Practice. USP Pharmacists’ Pharmacopeia. 2nd ed. Rockville: The United State Pharmacopeia; 2008. p. 957-60.
14. The Order of the Ministry of Health of Ukraine "On the WHO and FIP Guidelines" Proper Pharmacy Practice: Pharmacy Quality Standards: http://zakon.nau.ua/doc/?uid=1039.12816.0
15. Trissel LA. Handbook on injectable drugs. 17th ed. Maryland: American Society of Health- System Pharmacists; 2013.
16. Tykhonov OI, Yarnykh TH, Hrytsenko IS, Khokhlenkova NV. Extemporal Formulation (Technology, Analysis, Application): Methodical recommendations. Кyiv: Publishing House Agency of Medical Marketing; 2016. p. 352.
17. Tykhonov OI, Yarnykh TH. Pharmacy Technology of Drugs. Nova Knyha: Vinnytsia Ukraine; 2016. p. 536.