ABSTRACT:
Oral bioavailability of drugs is significantly low due to poor solubility. Approximately 40% of newly discovered drugs are poorly water soluble. To increase the bioavailability, various approaches like inclusion complexes, co solvents, hydrotropism etc. are used. In the lipid formulation of self emulsifying drug delivery system (SEDDS) utilizes the concept of drug solubilisation in situ when it comes in contact with aqueous media. The lipid SEDDS utilizes soft or hard gelatin capsules for filling of solubilized drug which shows problems of drug leakage, incompatibility etc. Telmisartan indicated for the treatment of hypertension was used as a model poor water soluble drug. Bioavailability of telmisartan is 40-52%. SEDDS were prepared for telmisartan using Captex355, Capmul MCM C8, and Tween 80. The ternary phase diagram were plotted to optimized the proportions of oil (10-50), surfactant (0-90) and co surfactant (0-90) The optimum amount of three agents leading to enhanced solubility was used. The solubilised drug was then adsorbed on the carrier made up of aluminium magnesium silicate and other diluents like flowac, MCC PH101. The physicochemical characterization of solubilised system for visual isotropy, self emulsification time, emulsion droplet size and similarly powder flow analysis of the adsorbed solubilised system on the carrier was done. In vitro drug release studies were carried out in pH 6.8 phosphate buffer. The SEDDS has shown nanoscale droplet size and total clarity on dilution with water. It has also shown good flowing properties. A complete drug release was observed within a period of 5-25 minutes. Hence the problem of efficiently delivering poorly soluble drugs would be solved by solid SEDDS.