ABSTRACT:
Metformin HCl is an oral anti-diabetic drug from the biguanide class. It is the first-line drug of choice for the treatment of type 2 diabetes, particularly in overweight and obese people and those with normal kidney function. Metformin is the most popular anti-diabetic drug in the India and one of the most prescribed drugs in the world. Ten brands (M1 to M10) of Metformin HCl tablets (850 mg) were evaluated for five in vitro parameters, both official and nonofficiali. viz; uniformity of weight, friability test, hardness test, thickness test and dissolution test. All the products met the requirements as per general specifications of Indian pharmacopoeia for tablet formulation. Drug content of all metformin tablets were within the range of 90% -110% of label claim.Dissoluiton profile was carried out, from the data it was noted that more than 97% drug release. The sample were then studied UV spectrophotometer at 233 nm for metformin HCL content. The release rate at different time interval were then determined. This sort of study is good indicator for the in vitro evaluation of idealness of commercial products. As per stability studies, there was no change or very slight change in the parameter studied for stability after first, second and third month of accelerated stability studies. Thus the formulation was found to be stable as per IP specification.