ABSTRACT:
There has been keen interest in the development of a novel drug delivery system. Novel drug delivery system aims to deliver the drug at a rate directed by the needs of the body during the period of treatment, and target the active entity to the site of action. A number of novel drug delivery systems have emerged encompassing various routes of administration, to achieve controlled and targeted drug delivery, magnetic microcarriers being one of them. These microcarriers include magnetic microspheres, magnetic liposomes, magnetic nanoparticles, magnetic resealed erythrocytes, magnetic emulsion etc. Magnetic nanoparticles and molecular magnetic labels have been used for great number of application in various areas of biosciences, targeted drug delivery, imaging and in bioseparation technology. The pipelines of pharmaceutical companies are believed to be drying up in many cases, and a number of blockbuster drugs will come off patent in the near-term. Using nanoparticles, it may be possible to achieve improved delivery of poorly water-soluble drugs by delivering drug in small particle size increase the total surface area of the drugs allowing faster dissolution in blood stream. Controlled release of drugs from nanostructured functional materials, especially nanoparticles (NPs), is attracting increasing attention because of the opportunities in cancer therapy and the treatment of other ailments. The potential of magnetic nanoparticles stems from the intrinsic properties of their magnetic cores combined with their drug loading capability and the biochemical properties. The main aim of this review to focus on the drug targeting by the magnetic nanoparticles.