ABSTRACT:
The main objective in the present investigation to improve the dissolution of celecoxib through the formulation of solid dispersion using water soluble carriers like PVP-K30 and Pearlitol-200 SD by solvent evaporation methods and to convert the optimized solid dispersion in fast dissolving tablet formulation. Celecoxib is new non-steroidal anti-inflammatory drug acting by an inhibition of the synthesis of prostaglandin by inhibiting the activity of the enzyme, cyclooxygenase-2 (COX-2). It is more selective for COX –2 than COX-1. Celecoxib is preferred over conventional NSAIDs as they may lead to serious gastrointestinal complications such as ulcer, severe bleeding and perforation, resulting in hospitalization and even death. Celecoxib is practically insoluble in water and peak plasma levels of celecoxib occur approximately 3 hrs after an oral dose. It is practically insoluble in aqueous fluids. The rate and extent of dissolution of the drug from any solid dosage form determines the rate and extent of absorption of the drug. In the case of poorly water-soluble drugs, dissolution is the rate-limiting step in the process of drug absorption. Celecoxib may pose dissolution related absorption problem. In context of the above principles, a strong need is felt to developed a solid unit dosage form that deliver celecoxib in the GIT in a form that dissolve very rapidly to reduce its onset time to produce quick pharmacological effect.