ABSTRACT:
Hydrodynamically Balanced Systems is an approach to increase the gastric residence time of drugs in stomach. This system is designed for site specific oral drugs with low bulk density than gastric fluids so as to buoyant the dosage form in stomach to increase the residence time of the drug. In the present investigation, an attempt has been made to design hydrodynamically balanced drug delivery systems for Pioglitazone using HPMC K4M and HPMC K15M polymers with different compression forces. The various batches of matrix tablets of Pioglitazone were prepared with varying concentrations of the polymers under direct compression method, using different compression forces. From the In vitro drug release studies (USP XXIV), the matrix tablets containing HPMC K15M, which was compressed at 6 Kg/cm2, showed 77.90% drug release in 12 hrs and showed better control of drug release. The in vitro release data was treated with mathematical equations, and was concluded that Pioglitazone released from the tablet followed Peppas model with non-Fickian diffusion. The results indicate that gas powered Hydrodynamically Balanced Tablets of Pioglitazone containing HPMC K15M provides a better option for absorption, controlled release action and improved bioavailability.