ABSTRACT:
The demand for mouth dissolving tablet (MDT) has been growing during the last decade especially for elderly and children who have swallowing difficulties. Chlorpromazine HCl is a potent anti-emetic, act by blocking D2 receptors in the Chemoreceptor trigger zone (CTZ) and antagonize apomorphine induced vomiting. In the present work, fast dissolving tablets of Chlorpromazine HCl were prepared by direct compression method using novel co-processed superdisintegrants consisting of crospovidone and sodium starch glycolate in the different ratios (1:1, 1:2 and 1:3). The developed superdisintegrants were evaluated for angle of repose, Carr’s index and Hausner’s ratio in comparison with physical mixture of superdisintegrants. The angle of repose of the developed excipients was found to be < 25°, Carr’s index in the range of 10-15% and Hausner’s ratio in the range of 1.11-1.14. Fast dissolving tablets of Chlorpromazine hydrochloride were prepared using the above co-processed superdisintegrants and physical mixtures of superdisintegrants evaluated for pre-compression and post-compression parameters. The drug-excipients interaction was checked and found negative through IR and DSC studies. Among all the formulations CP1 containing co-processed superdisintegrants of crospovidone and sodium starch glycolate in ratio 1:1 was found to be promising and has shown an in-vitro dispersion time of 19 sec, wetting time of 24 sec, almost complete release of drug within 8 minutes. Finally it was concluded that FDT of Chlorpromazine hydrochloride can be successfully formulated by direct compression method with improved patient compliance.