Development and Validation of RP-HPLC Method for Estimation of Olmesartan Medoxomil in Tablet Dosage Form

Nandini R. Pai; Seema S. Sawant

Research Journal of Pharmacy and Technology

ISSN

0974-360X (Online)
0974-3618 (Print)

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Development and Validation of RP-HPLC Method for Estimation of Olmesartan Medoxomil in Tablet Dosage Form

Author(s): Nandini R. Pai, Seema S. Sawant

Email(s): sachinpharma08@gmail.com

DOI: Not Available

Address: P. U. Kokulwar, K. G. Lakhane, S. S. Mitkare*
Department of Pharmaceutics, School of Pharmacy, Swami Ramanand Teerth Marathwada University, Nanded-431 606.
*Corresponding Author

Published In: Volume - 6, Issue - 11, Year - 2013

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ABSTRACT:
Simple and sensitive RP-HPLC methods are described for the determination of Olmesartan medoxomil. High-performance liquid chromatographic method was developed for the determination of Olmesartan medoxomil using Buffer : Acetonitrile (60:40, v/v) as the mobile phase and measuring the response at Lambda max 225 nm. The analysis was performed on a Kromasil C18 (150 X 4.6 mm), 5-micrometer column. The method was found to be accurate, with linearity ranging from 32 to 48 µ gm/ml for HPLC with a correlation coefficient (r2) 0.99979. Precision mean % assay was found to be 101.18% for HPLC. The mean % recovery was found to be 99.67% for HPLC

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Cite this article:
Nandini R. Pai, Seema S. Sawant. Development and Validation of RP-HPLC Method for Estimation of Olmesartan Medoxomil in Tablet Dosage Form. Research J. Pharm. and Tech. 6(11): November 2013; Page 1279-1284.

Cite(Electronic):
Nandini R. Pai, Seema S. Sawant. Development and Validation of RP-HPLC Method for Estimation of Olmesartan Medoxomil in Tablet Dosage Form. Research J. Pharm. and Tech. 6(11): November 2013; Page 1279-1284. Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2013-6-11-12