ABSTRACT:
Recent advances in novel drug delivery systems aimed in designing dosage forms which are convenient for manufacturing and administration, with fewer side effects, offering immediate release, with enhanced bioavailability thereby achieving better patient compliance. Orodispersible tablets (ODTs) is one such novel approach which helps to increase user acceptance by virtue of rapid disintegration, self administration without water or chewing. ODTs are solid unit dosage forms like the conventional tablets containing super disintegrants, which help them to disintegrate and/or disperse rapidly in the mouth within few seconds. In this review the authors highlighted on different criteria for selection of formulation excipients, technologies as conventional or patented and challenges to generate new strategies. Thus these formulations are particularly beneficial to the pediatric and geriatric patients affected by dysphagia. These tablets get converted into a suspension with the salivary fluid in the oral cavity thereby showing rapid onset of action with improved bioavailability. ODTs with good taste and flavor increases the acceptability of bitter drugs by patients, hence optimization of taste and flavor is a critical issue in these formulations. Better bioavailability and patient compliance along with several other benefits are the reasons for gained interest by industries for formulation development.