Author(s):
Hamid Khan, Mushir Ali, Alka Ahuja, Javed Ali
Email(s):
khanhamid770@gmail.com
DOI:
10.5958/0974-360X.2017.00197.4 
Address:
Hamid Khan1* Mushir Ali2, Alka Ahuja2, Javed Ali2
1Associate Professor, JK College of Pharmacy, Bilaspur, CG, India-495001
2Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India-110062
*Corresponding Author
Published In:
Volume - 10,
Issue - 4,
Year - 2017
ABSTRACT:
The aim of the presented work was formulation and in-vitro evaluation of bilayer tablets containing telmisartan as sustained release (SR) and hydrochlorothiazide as immediate release (IR) using HPMC. Tablets were evaluated via various quality control tests and in-vitro drug release studies. Drug release study was carried out hydrochloric acid buffer of pH 1.2 (0.1N) using USP paddle apparatus. The validated HPLC-UV method was applied to determine the amount of drugs released at different time intervals. Prepared tablets showed extended sustain release of telmisartan over a period of 20 h and hydrochlorothiazide as immediate release within 30 min.
Cite this article:
Hamid Khan, Mushir Ali, Alka Ahuja, Javed Ali. Formulation and In-Vitro Evaluation of FDC Bilayer Matrix Tablets Containing Telmisartan as Sustained Release and Hydrochlorothiazide as Immediate Release. Research J. Pharm. and Tech. 2017; 10(4): 1085-1090. doi: 10.5958/0974-360X.2017.00197.4
Cite(Electronic):
Hamid Khan, Mushir Ali, Alka Ahuja, Javed Ali. Formulation and In-Vitro Evaluation of FDC Bilayer Matrix Tablets Containing Telmisartan as Sustained Release and Hydrochlorothiazide as Immediate Release. Research J. Pharm. and Tech. 2017; 10(4): 1085-1090. doi: 10.5958/0974-360X.2017.00197.4 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2017-10-4-24