ABSTRACT:
In this work, thiadiazole derivatives were prepared by taking advantage of active sites in (2-amino-5-mercapto-1,3,4-thiadiazole) as base. The main hetrocyclic compounds (1,3,4-thiadiazole, oxazole) etc. 2-amino-5-mercapto-1,3,4-thiadiazole compound [1] was prepared by cyclic closure of thiosemicarbazide compound with anhydrous sodium carbonate and carbon disulfide. Oxidation of [1] via hydrogen peroxide, to have [2] which was treat with chloro acetyl chloride to get [3]. Preparation of oxazole ring [4] obtained from reacting of [3] with urea. Schiff bases [5 – 7] prepared by reacting [3] with different benzyl aldehyde. And Preparation of derivative [8 – 11], from reaction [3] with of hydrazine derivatives. Full characterization of the synthesized compounds was done by using of spectroscopic analysis such as FT-IR, 1H-NMR and C.H.N.S,
Cite this article:
Shetha. F. Al-Zubiady, Zainab. H. Kadhim Al-Khafaji, Iman. M. Mohamed. Synthesis, Characterization of New1,3,4-thiadiazole Derivatives with Studying their Biological Activity. Research J. Pharm. and Tech. 2018; 11(1): 284-293. doi: 10.5958/0974-360X.2018.00053.7
Cite(Electronic):
Shetha. F. Al-Zubiady, Zainab. H. Kadhim Al-Khafaji, Iman. M. Mohamed. Synthesis, Characterization of New1,3,4-thiadiazole Derivatives with Studying their Biological Activity. Research J. Pharm. and Tech. 2018; 11(1): 284-293. doi: 10.5958/0974-360X.2018.00053.7 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2018-11-1-53