ABSTRACT:
Background: Clindamycin is an important drug in the treatment of various Staphylococcal infections and inducible clindamycin resistance can lead to treatment failure with clindamycin. As methicillin resistance in Staphyloccusspp is quite common, Clindamycin could be used for the treatment of Methicillin resistance Staphylococcus aureus (MRSA) infections as well as infections produced by Coagulase negative staphylococcus (CoNS). Aims: To detect and to find the prevalence of clindamycin resistance among the clinical isolates of Staphylococcus spp. by D test method. Materials and Methods: A total of 573 clinical isolates were tested for inducible clindamycin resistance by disk approximation test (D test). Results: Among the clinical isolates Staphylococcus aureus were 376 (65.6%) whereas Coagulase negative Staphylococcus (CONS) were 197(34.4%). From the isolated strains-Methicillin resistant Staphylococcus aureus (MRSA) was 191(33.3%), Methicillin sensitive Staphylococcus aureus (MSSA) was 185(32.3%), Methicillin resistant coagulase negative staphylococcus (MRCONS) was 87(15.2%) and Methicillin sensitive coagulase negative staphylococcus (MSCONS) was 110(19.2%). Inducible clindamycin resistance (iMLSB) was observed to be 57 (15.2 %) in Staphylococcus aureus group and 43 (21.8 %) among Coagulase negative Staphylococcus group. Conclusion: Detection of inducible clindamycin resistance by a simple D test helps to avoid treatment failure with clindamycin.