Author(s):
Sunkara Mrunal Chaithanya, Mukthinuthalapati Mathrusri Annapurna
Email(s):
mrunal.chaitanya@gmail.com
DOI:
10.5958/0974-360X.2019.00843.6 
Address:
Sunkara Mrunal Chaithanya*, Mukthinuthalapati Mathrusri Annapurna
Department of Pharmaceutical Analysis & Quality Assurance, Gandhi Institute of Technology and Management, GITAM Institute of Pharmacy, GITAM (Deemed to be University),
Visakhapatnam, Andhra Pradesh-530045, India.
*Corresponding Author
Published In:
Volume - 12,
Issue - 10,
Year - 2019
ABSTRACT:
Amlodipine is a calcium channel blocker. Atorvastatin is used for lowering the cholesterol. A new stability indicating liquid chromatographic method (RP-UPLC) has been proposed for the simultaneous estimation of Atorvastatin and Atorvastatin. Acquity UPLC HSS C18 column was used for the chromatographic study and a mobile phase mixture consisting of 0.1% Formic acid: Acetonitrile: Methanol (0.1:45: 55, v/v)/ 0.3/220 (Flow rate: 0.3 mL/min) (PDA detector 220 nm) was used for the elution of these two drugs. Stress degradation studies were performed and the method was validated as per ICH guidelines.
Cite this article:
Sunkara Mrunal Chaithanya, Mukthinuthalapati Mathrusri Annapurna. Stability indicating RP-UPLC method for the simultaneous determination of Atorvastatin and Amlodipine. Research J. Pharm. and Tech 2019; 12(10):4867-4872. doi: 10.5958/0974-360X.2019.00843.6
Cite(Electronic):
Sunkara Mrunal Chaithanya, Mukthinuthalapati Mathrusri Annapurna. Stability indicating RP-UPLC method for the simultaneous determination of Atorvastatin and Amlodipine. Research J. Pharm. and Tech 2019; 12(10):4867-4872. doi: 10.5958/0974-360X.2019.00843.6 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2019-12-10-53