Author(s):
Amaresh Chandra Sahoo, Sunil Kumar Kanungo, Subas Chandra Dinda, Sujit Dash, Suchismita Pani
Email(s):
amareshchandrasahoo@gmail.com
DOI:
10.5958/0974-360X.2019.00861.8
Address:
Amaresh Chandra Sahoo1*, Sunil Kumar Kanungo2, Subas Chandra Dinda3, Sujit Dash4, Suchismita Pani5
1School of Pharmaceutical Education and Research, Behampur University, Berhampur, Ganjam, Odisha, India
2,4Institute of Pharmacy and Technology, Salipur, Cuttack, Odisha, India
3College of Health Sciences, Mekelle University, Mekelle, Ethiopia.
5Jeypore College of Pharmacy, Jeypore, Odisha
*Corresponding Author
Published In:
Volume - 12,
Issue - 10,
Year - 2019
ABSTRACT:
The objectives and purpose of the present research work are to improve the solubility and dissolution rate of lovastatin. Solid dispersions of lovastatin were prepared by fusion method by using two selected hydrophilic meltable carriers vis-a-vis gelucire 44/14 and polyethyleneglycol (PEG6000). Neucilin US2 was used as an adsorbent, flow and compressibility promoter and booster. Solid dispersions were evaluated for solubility, phase solubility, flowability, compressibility, Fourier transform infrared spectra (FT-IR), differential scanning calorimetry (DSC) and in-vitro dissolution. Solubility studies showed 8 and 15 fold maximization in solubility for PEG6000 and gelucire 44/14 based solid dispersions respectively. The Gibbs free energy ?Gtr° values were negative for both the carriers indicating spontaneous nature of solubilization. FT-IR and DSC spectra demontrated that drug and carriers are compatible with each other. In-vitro dissolution studies demontrated that gelucirre 44/14 based solid dispersion dissolved more than 95% of lovastatin within 30 min. Solid dispersion exhibiting highest solubility and dissolution rate was compressed and formulated into immediate release (IR) tablets incorporating crosscaramellose sodium as superdisintegrant. In vitro dissolution studies for solid dispersion based immediate release tablet, exhibited more than 90% drug dissolution in 30 min(F28). The adsorbent, Neucilin US2 reduced stickiness, imparted good flow and compressibility to solid dispersions. Among the two carriers, gelucire 44/14 demonstrated better solubility and dissolution enhancement potential for lovastatin.
Cite this article:
Amaresh Chandra Sahoo, Sunil Kumar Kanungo, Subas Chandra Dinda, Sujit Dash, Suchismita Pani. Formulation Development of Immediate Release Solid Dispersion Tablets of Lovastatin with Enhanced Dissolution. Research J. Pharm. and Tech. 2019; 12(10):4963-4972. doi: 10.5958/0974-360X.2019.00861.8
Cite(Electronic):
Amaresh Chandra Sahoo, Sunil Kumar Kanungo, Subas Chandra Dinda, Sujit Dash, Suchismita Pani. Formulation Development of Immediate Release Solid Dispersion Tablets of Lovastatin with Enhanced Dissolution. Research J. Pharm. and Tech. 2019; 12(10):4963-4972. doi: 10.5958/0974-360X.2019.00861.8 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2019-12-10-71