Author(s):
Sasikala Maadwar, Rajitha Galla, Santhosh K. G
Email(s):
maadwarsasikala@gmail.com
DOI:
10.5958/0974-360X.2019.00179.3 
Address:
Sasikala Maadwar*1,2, Rajitha Galla1, Santhosh K. G2
1Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam, Tirupati, India.
2Medicinal Chemistry and Pharmacology Division, Indian Institute of Chemical Technology, Hyderabad, India.
*Corresponding Author
Published In:
Volume - 12,
Issue - 3,
Year - 2019
ABSTRACT:
A facile and an efficient synthesis of 3,3-disubstituted oxindole derivatives were synthesised by treating isatins with electron rich benzene derivatives at room temperature. The compounds were evaluated for cytotoxic activity against human breast cancer cells (MCF7) and human ovarian carcinoma cells (SKVO3) by using MTT assay. Compounds 5(9.2µM and 9.5µM) and 7(8.0µM and 10.4µM) exhibited relatively higher cytotoxic activity against both MCF7 and SKVO3 cell lines, respectively.
Cite this article:
Sasikala Maadwar, Rajitha Galla, Santhosh K. G. A Facile and An Efficient Synthesis of 3,3-Disubstituted Oxindole Scaffolds and their Cytotoxic Properties. Research J. Pharm. and Tech. 2019; 12(3): 1091-1095. doi: 10.5958/0974-360X.2019.00179.3
Cite(Electronic):
Sasikala Maadwar, Rajitha Galla, Santhosh K. G. A Facile and An Efficient Synthesis of 3,3-Disubstituted Oxindole Scaffolds and their Cytotoxic Properties. Research J. Pharm. and Tech. 2019; 12(3): 1091-1095. doi: 10.5958/0974-360X.2019.00179.3 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2019-12-3-18