ABSTRACT:
The study is intended to asses serum levels of Serotonin, malondialdehyde (MDA) and glutathione (GSH) in type 2 diabetic mellitus patients in comparison healthy groups of males, also correlation among Serotonin, MDA and GSH of DM patients. The study was conducted on selected 60 type 2 diabetic patients of males that attending to the diabetes mellitus center in Al-Sadder Teaching City in Al- Najaf province, Iraqi and a group of 60 apparently healthy subjects of males were included as a control group. The D M patients are divided into three groups of ages (15-19y), (20-39y) and (40-60 y). The Study was carried out from June 2018 to October 2018.The patients' age was ranging from 15 to 60 years old. The results also revealed that significant increase (p<0.05) in serum levels Serotonin and MDA in diabetic patients in comparing with healthy groups, while a significant decrease (p<0.05) in serum level GSH in diabetic patients in comparing with healthy groups. The results show that serum Serotonin level no significant (p>0.05) between (20-39y) and (40-60y) ages of D M patients, But there is a significant increase (p<0.05) in these ages groups than the ages (15-19y). The results show that serum MDA level increase significantly (p<0.05) with increasing age of patients and the ages (40-60y) are highly significant(p<0.05) than (20-39-54y) and (15-19y). The results show that serum GSH level no significant (p>0.05) between the ages (20-39y) and (40-60y) groups of D M patients, But there is a significant increase (p<0.05) in the ages (15-19y) than the ages (20-39y) and (40-60y) groups. The results have been shown a significant positive correlation (P<0.05) between serotonin and MDA in DM patients, and a significant negative correlation (P<0.05) between (serotonin and GSH), (MDA and GSH) in DM patients. Conclusion: The present study concluded that Serotonin, MDA and GSH were marker for detection and diagnosis of type 2 diabetic mellitus males patients.