Author(s):
Suresh Gandi, A. Manikandan, S. Venkat Rao
Email(s):
suresh84gandi@yahoo.co.in
DOI:
10.5958/0974-360X.2020.00050.5 
Address:
Suresh Gandi1, A. Manikandan1, S. Venkat Rao2
1Department of chemistry, Bharath Institute of Higher Education and Research, Selaiyur, Chennai-600073, Tamilnadu, India
2SMS Pharmaceuticals Ltd, R&D Centre (A DSIR approved), Gagillapur, Telangana-500047, India
*Corresponding Author
Published In:
Volume - 13,
Issue - 1,
Year - 2020
ABSTRACT:
A simple, Accurate, precise method was developed for the simultaneous determination of the Ivabradine and Metoprolol in Pharmaceutical dosage form. Chromatogram was run through SB C8 100 x 3.0mm, 1.8mm. Mobile phase containing Buffer 0.01N Potassium dihydrogen ortho phosphate: Acetonitrile chosen in the ratio 50:50v/v was pumped through column at a flow rate of 0.3 ml/min. Temperature and Wave length was optimized at 30°C and 260 nm independently. Percentage of recovery was obtained as 100.03% and 100.03% for Ivabradine and Metoprolol individually. LOD, LOQ values obtained from regression equations of Ivabradine and Metoprolol were 0.03, 0.08 and 0.12, 0.35 respectively.
Cite this article:
Suresh Gandi, A. Manikandan, S. Venkat Rao. Novel Stability indicating RP-UPLC Method for simultaneous Determination of Ivabradine and Metoprolol drug materials in bulk and their Pharmaceutical Dosage Forms. Research J. Pharm. and Tech. 2020; 13(1):250-254. doi: 10.5958/0974-360X.2020.00050.5
Cite(Electronic):
Suresh Gandi, A. Manikandan, S. Venkat Rao. Novel Stability indicating RP-UPLC Method for simultaneous Determination of Ivabradine and Metoprolol drug materials in bulk and their Pharmaceutical Dosage Forms. Research J. Pharm. and Tech. 2020; 13(1):250-254. doi: 10.5958/0974-360X.2020.00050.5 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2020-13-1-50