The ring system in which a benzene ring is fused to the 4, 5-positions of imidazole is designated as benzimidazole. Benzimidazole is a significant compound with a broad range of biological activity varying from anti-anthelmintic, anti-viral, anti-hypertensive, antifungal and antibacterial activity. Benzimidazole has shown promising operations in the therapy of several illness with its derivatives. As a significant pharmacopoeia and a privileged structure, it get a lot of attention. In addition, benzimidazole derivatives are structural isosters of naturally occurring nucleotides that allow them to readily communicate with the living system biopolymers. There is a dire need for the discovery and development of new antimicrobial agents after several experiments for a better resistance of microorganisms towards antimicrobial agents become a serious health problem for a few years in earlier. Due to its antimicrobial activities, benzimidazole derivatives were screened for their antifungal and antibacterial activities. In this study, I have tried piperazine derivatives with imidazole and benzamine respectively on different positions of heterocyclic structure. FTIR, 1H NMR and mass spectrometry recognized the compounds produced. All synthesized compounds were screened against conventional strains for their antibacterial and antifungal operations: gram positive is B.subtilis, and S.aureus and gram negative are E. coli and P. aeruginosa. Antifungal activity was screened against C. Albicans and A. niger. Disc diffusion technique was used to carry out the antibacterial and antifungal operations of all sample compounds.
Cite this article:
Kartik Kaushik, Harsh Bhardwaj, Gyanendra Kumar Sharma. Synthesis and biological evaluations of some novel Benzimidazole Derivatives. Research J. Pharm. and Tech. 2020; 13(1): 368-372. doi: 10.5958/0974-360X.2020.00073.6
Kartik Kaushik, Harsh Bhardwaj, Gyanendra Kumar Sharma. Synthesis and biological evaluations of some novel Benzimidazole Derivatives. Research J. Pharm. and Tech. 2020; 13(1): 368-372. doi: 10.5958/0974-360X.2020.00073.6 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2020-13-1-73