Author(s): Lavanya M, Chinna Eswaraiah M, Jaya S


DOI: 10.5958/0974-360X.2020.00891.4   

Address: Lavanya M, Chinna Eswaraiah M, Jaya S*
Department of Pharmaceutics, Anurag Pharmacy College, Ananthagiri, Kodad, Suryapet - 508206, Telangana, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 11,     Year - 2020

The present study was carried out to prolong the gastric residence time of propranolol hydrochloride by designing its sustained release floating tablets using natural gum (xanthan gum) as cost effective, nontoxic, easily available and suitable hydrophilic matrix system compared with semi synthetic cellulosic derivative (hydroxy propyl cellulose) with respect to in-vitro drug release rate and rate of hydration of the polymer. The tablets were prepared by direct compression method using various drug to polymer (D:P) ratios. Sodium bicarbonate was used as gas generating agent. Tablets were evaluated for various parameters like floating lag time, duration of floating, content uniformity and in-vitro drug release profile. Fourier transform infrared (FTIR) and thermal analysis differential scanning colorimetry (DSC) studies of the formulation revealed there was no chemical interaction between drug, polymer and excipients. The floating lag time of all the formulations was found to be less than 3 min. The drug release mechanism from floating tablets was evaluated on the basis of Higuchi and Peppas. The release exponent, n value of the formulations ranged from 0.40 to 0.58, indicated non- fickian transport mechanism.

Cite this article:
Lavanya M, Chinna Eswaraiah M, Jaya S. Design, Development and In-vitro Characterization of Floating tablets of Propranolol hydrochloride. Research J. Pharm. and Tech. 2020; 13(11):5088-5094. doi: 10.5958/0974-360X.2020.00891.4

Lavanya M, Chinna Eswaraiah M, Jaya S. Design, Development and In-vitro Characterization of Floating tablets of Propranolol hydrochloride. Research J. Pharm. and Tech. 2020; 13(11):5088-5094. doi: 10.5958/0974-360X.2020.00891.4   Available on:

1.    Vyas SP, Roop K. Khar. Controlled Oral Administration.  Controlled Drug Delivery. Vallabh Prakashan, Delhi, India 2012. P. 156-157.
2.    Arora S, Javeed Q, Alka Ahuja, Khar RK, Baboota S. Floating drug delivery systems: A review. AAPS Pharm Sci Tech. 2005; 6(3): 372-379.
3.    Swathi J, Anuruddha RC and Bhanudas K. Formulation and evaluation of gastroretentive drug delivery system of propranolol hydrochloride. AAPS Pharm Sci Tech 2009; 10(3):1071-1078.
4.    Sundra S, Hendrik, Karsten M. Characterization of poly (vinyl acetate) based floating matrix tablets. Journal of controlled release. 2008; 126(2): 149-155.
5.    Saritha D, Ganesh KY, Damayanthi. D and Kiran KV. Formulation design, development of gastro retentive floating tablets of propranolol. Asian Journal of Pharmaceutics. 2018; 12 (2) (Suppl): 747-751.
6.    Mohana K L, Prabhakar RB, Srinivasa RK and Ashok KK. Formulation and evaluation of floating bilayer tablets of propranolol hydrochloride. Indian Journal of Research in Pharmacy and Biotechnology. 2016; 4:69-71.
7.    Jaya S and Divya S. Formulation and invitro evaluation of matrix tablets of metoclopramide hydrochloride. International Journal of Applied Pharmaceutics. 2019; 11(3): 25-30.
8.    Atif A, Iqbal M, Naveed A, Haji MSK, Aftab U, Minahaj U and Tahir MK. Assessment of xanthan gum based sustained release matrix tablets containing highly water-soluble propranolol HCL. Acta Poloniac Pharmaceutics-drug Research 2013; 70(2): 283-289.
9.    Jaya S and Amala V. Formulation and invitro evaluation of oral disintegrating tablets of amlodipine besylate. International Journal of Applied Pharmaceutics 2019; 11(1): 49-54.
10.    Sirisha VNL, Chinna eswaraiah M and Sambasiva Rao A. Formulation and evaluation of karaya gum microspheres of cromolyn sodium: Treatment of ulcerative colitis. International Research Journal of Pharmacy. 2017, 8(10):182-188.
11.    Chinna Eswaraih M and Jaya S. Formulation and invitro evaluation of metformin hydrochloride sustained release tablets. Journal of Drug Delivery and Therapeutics. 2019; 9(4):24-29.
12.    Roop K. Khar, Vyas SP, Farhan JA and Gaurav K. Jain. Lachman / Lieberman’s the theory and practice of industrial pharmacy. Fourth edition. CBS Publishers and Distributors Pvt. Ltd, 2013. 479-488.
13.    Gharti KP, Thapa P, Budhathoki U, Bhargava A. Formulation and invitro evaluation of floating tablets of hydroxy propyl methyl cellulose and polyethylene oxide using ranitidine hydrochloride as a model drug. J Young Pharmacist. 2012; 4(4): 201-208.
14.    Kiran C, S. Umadevi and Subhash V. Floating matrix dosage form for propranolol hydrochloride based on gas formation technique: Development and in vitro evaluation. Scientia Pharmaceutica. 2010; 78: 927-939.
15.    Suvakanta D, Narasimha MP, Lilakanta N and Prasanta C. Kinetic modeling on drug release from controlled drug delivery systems. Acta Poloniae Pharm Drug Res. 2010; 67:217-223.
16.    Chakraborty T, Natasha, Vipin S and Rubi. Formulation and evaluation of controlled release floating tablets of cefixime using hydrophilic polymers. International Research Journal of Pharmacy. 2019; 10(1):171-175.
17.    Chinna EM and Jaya S. Design and in-vitro characterization of floating tablets of metronidazole. Asian Journal of Pharmaceutical and Clinical Research. 2019; 12(3):539-544.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Recent Articles


Not Available