Gayathri M, Mithra Chandrasekaran, Arun Radhakrishnan, Gowthamarajan Kuppusamy, Sachin Kumar Singh
Gayathri M1, Mithra Chandrasekaran1, Arun Radhakrishnan1, Gowthamarajan Kuppusamy1* Sachin Kumar Singh2
1Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty. Nilgiris, Tamil Nadu, India.
2School of Pharmaceutical Sciences, Lovely Professional University, Punjab.
Volume - 13,
Issue - 12,
Year - 2020
Background: Badam gum (BG), a plant exudate is obtained from Terminalia catappa. As BG is a novel polysaccharide, physico-chemical characterization was performed in order to establish its suitability as pharmaceutical excipient. Natural Polymers are economical, abundant, non-toxic and potentially Bio-degradable. Objective: To Characterize the Badam gum and to prepare and evaluate paracetamol tablet with different ratios of Badam gum. Method: Badam gum was prepared and subjected to biochemical tests (Molisch’s, Benedicts and fehling’s test) and preformulation studies. Direct Compression of paracetamol tablets using different ratios of Badam gum (0.06g, 0.12g, 0.24g, 0.36g, 0.48g, 0.6g, 0.72g, 0.84g) as disintegrant and MCC (5.94, 5.88, 5.76, 5.64, 5.52, 5.4, 5.28, 5.16) was carried out. Tablets were evaluated for Physicomechanical Properties, disintegration and dissolution. Results: Positive results obtained in the preliminary tests in the identification of Badam gum. Swelling Index was found to be 220%. DSC and FTIR Studies revealed that Badam gum is compatible with the drug. Hardness of formulation F5 was found to be 6 and other formulations was found to be 4. Disintegration time of F2 was found to be 90 Sec, whereas F6 disintegrated at 5 min 25 Sec. In in vitro dissolution studies, on comparing to all formulation, increasing the concentration of badam gum retards the faster release of Paracetamol. Conclusion: In this study, paracetamol tablets were prepared with different ratios of Badam gum. From the study it can be concluded that 2.5% of Badam gum can be used as disintegrant.
Cite this article:
Gayathri M, Mithra Chandrasekaran, Arun Radhakrishnan, Gowthamarajan Kuppusamy, Sachin Kumar Singh. Optimizing Badam gum towards tableting excipients. Research J. Pharm. and Tech. 2020; 13(12):6176-6181. doi: 10.5958/0974-360X.2020.01077.X
Gayathri M, Mithra Chandrasekaran, Arun Radhakrishnan, Gowthamarajan Kuppusamy, Sachin Kumar Singh. Optimizing Badam gum towards tableting excipients. Research J. Pharm. and Tech. 2020; 13(12):6176-6181. doi: 10.5958/0974-360X.2020.01077.X Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2020-13-12-92
1. Overview of Pharmaceutical excipients used in tablets and capsules. Pharma-excipients.https://www.pharmaexcipients.com/news/overview-of-pharmaceutical-excipients-used-in-tablets-and-capsules/
2. Shilpa P Chaudhari and Pradeep S Patil. Pharmaceutical Excipients: A review. International Journal of Advances in Pharmacy, Biology and Chemistry. 2012; 1(1).
3. Drug Formulation. http://www.medicinalchemistryproject.info/ formulation.html
4. Charles G. Gebelein, et al. Cosmetic and Pharmaceutical Applications of Polymers. 1991.
5. Phani Kumar G.K, Gangarao battu, et al. Isolation and Evaluation of Tamarind Seed Polysaccharide being used as a Polymer in Pharmaceutical Dosage Forms. Research Journal of Pharmaceutical, Biological and Chemical Sciences. Research Journal of Pharmaceutical, Biological and Chemical Sciences 2(2): 274-290.
6. Girish K Jani, Dhiren P Shah, et al. Gums and mucilages: versatile excipients for pharmaceutical formulations. Asian Journal of Pharmaceutical Sciences 2009, 4 (5): 308-322
7. Sarojini, Deepthi S. Kunam, et al. Effect of Natural Almond Gum as A Binder in The Formulation of Diclofenac Sodium Tablets. International Journal of Pharmaceutical Sciences and Research. 2010: 55-60.
8. Om Prakash Pal, Malviya R, Bansal V, Sharma PK. Rosin an Important Polymer for Drug Delivery: A Short Review. International Journal of Pharmaceutical Sciences Review and Research. 2010; 3(1):35-37
9. Yuvaraj D, Suvasin B et al. Resins as a Preservative for Fruits and Vegetables. International Journal of Current Microbiology and Applied Sciences (IJCMAS). 2016.5(9): 120-130.
10. Farooq U, Malviya R et al. Design and Development of Multi Particulate System for Targeted Drug Delivery Using Natural Polymer. Pharmaceutica Analytica Acta. 2015.
11. Meka VS, Nali SR, et al. Characterization and In Vitro Drug Release Studies of a Natural Polysaccharide Terminalia catappa Gum (Badam Gum). AAPS Pharm Sci Tech. 2012. 13(4):1451-1464.
12. Ravindrakullai reddy M and Manjunath K. Pharmaceutical Applications of Natural Gums, Mucilages and Pectins - A Review. International Journal of Pharmaceutical and Chemical Sciences. 2013.
13. Farooq U, Sharma PK etal.. Extraction and Characterization of Almond (Prunus sulcis) Gum as Pharmaceutical Excipient. 2014;14 (3): 269-274.
14. Qualitative and Quantitative tests for Carbohydrates. http://www.biologydiscussion.com/carbohydrates/test/qualitative-and-quantitative-tests-for-carbohydrates/13042
15. Vicky D Ranpura, Atul Kathiriya, et al. Development and Characterization of Sustained Release Bilayered Tablet of Valsartan and Pioglitazone Hcl. Pharma Science Monitor. 2013; 4: 311-326.
16. Ramesh K. V. R. N. S., Walayat F.S, et al. Design and Evaluation of Sustained Release Matrix Tablets of Indomethacin by Employing Gelucires and Badam Gum. Asian Journal of Pharmaceutics. 2015; 9
17. Govedarica B, Injac R, et al. Formulation and evaluation of immediate release tablets with different types of paracetamol powders prepared by direct compression. African Journal of Pharmacy and Pharmacology. 2011; 5(1):31-41.
18. Haritha B. A Review on Evaluation of Tablets. Journal of Formulation Science and Bioavailability. 2017; 1:1.
19. Sharma D. Formulation Development and Evaluation of Fast Disintegrating Tablets of Salbutamol Sulphate for Respiratory Disorders. ISRN Pharmaceutics. 2013:1–8.
20. Basak SC, Jayakumar Reddy BM and Lucas Mani KP. Formulation and release behavior of sustained release ambroxol hydrochloride HPMC matrix tablet. Indian Journal of Pharmaceutical Sciences. 68(5):594-598.