Author(s):
Karthick R K, Kavitha J, Lakshmi K S
Email(s):
kavitha0208@gmail.com
DOI:
10.5958/0974-360X.2020.00145.6 
Address:
Karthick R K, Kavitha J*, Lakshmi K S
Department of Pharmaceutical Analysis, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur-603203, Kancheepuram district, Tamil Nadu, India.
*Corresponding Author
Published In:
Volume - 13,
Issue - 2,
Year - 2020
ABSTRACT:
The present abstract employs the use of Multivariate Calibration Technique for the assessment of Terbutaline sulphate in the marketed pharmaceutical formulation. The multivariate calibration technique was established by the use of linear regression equation employing the relationship at five different concentration levels and its absorbance recorded at five selected wavelengths around the ?max of the drug. The method was observed to be linear over a concentration range of 30-90 µg/mL with a correlation coefficient value more than 0.99. The ?max of Terbutaline sulphate was found to be 277 nm. The developed method was found to be simple, rapid, accurate and precise in accordance to the ICH protocol Q2(R1). This statistical methodology gives ideal outcomes by eliminating the deviations emerging out of instrumental or experimental conditions.
Cite this article:
Karthick R K, Kavitha J, Lakshmi K S. Quantification of Terbutaline Sulphate in Pharmaceutical Formulation by UV Spectrophotometric aided Multivariate Calibration Technique. Research J. Pharm. and Tech 2020; 13(2):767-773. doi: 10.5958/0974-360X.2020.00145.6
Cite(Electronic):
Karthick R K, Kavitha J, Lakshmi K S. Quantification of Terbutaline Sulphate in Pharmaceutical Formulation by UV Spectrophotometric aided Multivariate Calibration Technique. Research J. Pharm. and Tech 2020; 13(2):767-773. doi: 10.5958/0974-360X.2020.00145.6 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2020-13-2-49