Author(s): Raghu Raj Naik, Choppala Asha Deepti, Sistla Mounica Prathyusha, Mukthinuthalapati Mathrusri Annapurna

Email(s): rajraghu496@gmail.com

DOI: 10.5958/0974-360X.2020.00254.1   

Address: Raghu Raj Naik*, Choppala Asha Deepti, Sistla Mounica Prathyusha, Mukthinuthalapati Mathrusri Annapurna GITAM Institute of Pharmacy, GITAM (Deemed to be) University, Visakhapatnam-530045, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 3,     Year - 2020


ABSTRACT:
Methenamine hippurate is an antibiotic used for the treatment of urinary tract infections but no other types of bacterial infections (such as in the blood) or for viral infections (such as the common cold or flu). Methenamine hippurate acts as an antibiotic that stops the growth of bacteria in urine. Methenamine hippurate helps to make the urine acidic. When the urine is acidic, Methenamine hippurate turns into formaldehyde to kill the bacteria. Four new spectrophotometric methods have been proposed for the estimation of Methenamine hippurate in pharmaceutical formulations using acetate buffer (pH 2.4) and borate buffer (pH 9.0), phosphate buffer (pH 7.0) and phosphate buffer (pH 8.0). Methenamine hippurate has shown absorption maxima at 230 nm in all the methods. Methenamine hippurate obeys Beer-Lambert’s law over the concentration range 10-80 µg/ml in all the methods and all the methods were validated as per ICH guidelines.


Cite this article:
Raghu Raj Naik, Choppala Asha Deepti, Sistla Mounica Prathyusha, Mukthinuthalapati Mathrusri Annapurna. New Validated Analytical Methods for the Determination of Methenamine Hippurate (An Antibiotic Agent). Research J. Pharm. and Tech 2020; 13(3):1386-1390. doi: 10.5958/0974-360X.2020.00254.1

Cite(Electronic):
Raghu Raj Naik, Choppala Asha Deepti, Sistla Mounica Prathyusha, Mukthinuthalapati Mathrusri Annapurna. New Validated Analytical Methods for the Determination of Methenamine Hippurate (An Antibiotic Agent). Research J. Pharm. and Tech 2020; 13(3):1386-1390. doi: 10.5958/0974-360X.2020.00254.1   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2020-13-3-59


REFERENCES:

1.       Dreyfors JM, Jones SB and Sayed Y. Hexamethylenetetramine: a review. American Industrial Hygiene Association. Journal, 1989; 50(11): 579-585.

2.     Chiravi Pavitrapok, Williams DA. Determination of Methenamine, Methenamine mandelate and Methenamine hippurate in pharmaceutical preparations using ion-exchange HPLC. Journal of Pharmaceutical and Biomedical Analysis, 2006; 40(5): 1243-1248.

3.       Mirza T, George RC, Bodenmiller JR, Belanich SA. Capillary gas chromatographic assay of residual Methenamine hippurate in equipment cleaning validation swabs. , 1998; 16(6): 939-950.

4.       Lim JK, Chen CCC. Spectrophotometric determination of Methenamine and its salts by 2‐hydrazinobenzothiazole. Journal of Pharmaceutical Sciences, 1973; 62(9): 1503-1504. 

5.       Taha AM, El-Rabbat NA, and Fattah FA. Spectrophotometric assay of Hexamethylene tetramine. The Analyst, 1980; 105(1251), 568-574.

6.       Madsen GL and Jaselskis B. Spectrophotometric determination of Hexamethylenetetramine. Analyst, 1992; 117(11), 1785-1788.

7.       Koga M, Shinohara R and Akiyama T. Gas chromatographic determination of trace amounts of Hexamethylenetetramine in water using an iodine charge-transfer complex. Analytical Sciences, 1985; 1(4): 381-384.

8.       Mehdi Taghdiri, Yadollah Yamini and Ali Moloudi. Micro determination of Methenamine in the Presence of Formaldehyde by Solid Phase Spectrophotometry. ISRN Spectroscopy

1.       2012; Article ID 975716.

9.     Maruthamuthu Balasubramanian, Sathiah Thennarasu, Thankiah Sudhakaran, Paramasivam Thirumalai Perumal. Spectrophotometric and fluorimetric determination of Hexamine in pure form and its pharmaceutical formulation. Biological and Pharmaceutical Bulletin. 2003; 26(8): 1211-1214.

10.    Madsen GL, Crumrine DS and Jaselskis B. Proton nuclear magnetic resonance determination of Hexamethylenetetramine in the presence of formaldehyde and urine. Analyst, 1996; 121(4): 567-570.

11.    Strom G Jr. and Jun HW. Separation and quantitation of Methenamine in urine by ion-pair extraction. Journal of Pharmaceutical Sciences, 1986; 75(4): 416-420.

12.    Xing Xu, Xiaoming Zhang, Emmanuel Duhoranimana, Yan Zhang, Ping Shu. Determination of Methenamine hippurate residues in edible animal tissues by HPLC-MS/MS using a modified QuEChERS method: Validation and pilot survey in actual samples. Food Control, 2016; 61: 99-104.

13.    Xing Xu, Xiaoming Zhang , Shabbar Abbas, Emmanuel Duhoranimana, Feijin Peng, Ping Shu. Methenamine hippurate in dairy products by isotope dilution gas chromatography coupled with triple quadrupole mass spectrometry: Method validation and occurrence. Food Control, 2015; 57: 89-95.

14.    ICH Q2 [R1] validation of analytical procedures: Text and Methodology: November 2005.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank

Journal Policies & Information


Recent Articles




Tags


Not Available