Author(s):
Selvaraj Sudhakar, Jibi Paul, Senthil Selvam P, Mahendranath P
Email(s):
sudhakar.physio@drmgrdu.ac.in
DOI:
10.5958/0974-360X.2020.00643.5 
Address:
Selvaraj Sudhakar1, Jibi Paul2, Senthil Selvam P3, Mahendranath P4
1Associate Professor, Faculty of Physiotherapy, Dr. M. G. R. Educational and Research Institute, Maduravoyal, Chennai– 600095, Tamil Nadu, India.
2Professor, Faculty of Physiotherapy, Dr. M. G. R. Educational and Research Institute, Maduravoyal, Chennai– 600095, Tamil Nadu, India.
3Professor, School of Physiotherapy, VELS Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai - 600043, Tamil Nadu, India.
4Associate Professor, Department of Pathology, A.C.S Medical College and Hospital, Dr. M. G. R. Educational and Research Institute, Velappanchavadi, Chennai - 600 077, Tamil Nadu, India.
*Corresponding Author
Published In:
Volume - 13,
Issue - 8,
Year - 2020
ABSTRACT:
Objective: To investigate the effects of diclofenac phonophoresis and autogenic inhibition muscle energy technique on serum creatine kinase level compared to control group on delayed onset muscle soreness in novice athletes. Materials and Methods: Forty eight novice athletes were recruited based on selection criteria and simple random sampling technique through lottery method was used to participate in this single blind multi group repeated measures design, a pilot randomized clinical trial. After collection of demographic data, the athletes were allotted to the group based on the chits what they have picked. Group A subjects were treated with diclofenac phonophoresis, Group B subjects were treated with autogenic inhibition technique and Group C subjects were control group. An Epley formula was used for the calculation of one repetition maximum for elbow flexor muscle followed by 80 % 1 RM was calculated for all the subjects. Blood samples were collected at the baseline and 24 hours, 48 hours, 72 hours and 96 hours after inducing delayed onset of muscle soreness. Creatine kinase biochemical marker was considered as a dependent variable and values displayed in the instrument were noted. Result: On comparing creatine kinease level, there exists no significant difference between the three groups at the baseline and 48 hour measurements at (P > 0.05) and statistically significant difference was found between three groups at 24 hours,72 hours and 96 hours at (P < 0.05). Anova with repeated measures showed that the creatine kinase measures an overall changes within three groups at (P < 0.05). Conclusion: Autogenic inhibition is an effective muscle energy technique to reduce the creatine kinase level following eccentric exercise and can facilitate the recovery faster and prepare the novice athletes for early participation in sports.
Cite this article:
Selvaraj Sudhakar, Jibi Paul, Senthil Selvam P, Mahendranath P. Serum Creatine Kinase Response on Exercise Induced Delayed Onset Muscle Soreness: A Pilot Single Blind Randomized Clinical Trial. Research J. Pharm. and Tech. 2020; 13(8):3638-3642. doi: 10.5958/0974-360X.2020.00643.5
Cite(Electronic):
Selvaraj Sudhakar, Jibi Paul, Senthil Selvam P, Mahendranath P. Serum Creatine Kinase Response on Exercise Induced Delayed Onset Muscle Soreness: A Pilot Single Blind Randomized Clinical Trial. Research J. Pharm. and Tech. 2020; 13(8):3638-3642. doi: 10.5958/0974-360X.2020.00643.5 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2020-13-8-16
REFERENCES:
1. Talag. T (1973) Residual muscle soreness as influenced by concentric, eccentric and static contraction, Research Quarterly, 44, 458-69.
2. Armstrong, R.B (1984) Mechanism of exercise-induced delayed onset of muscular soreness : A brief review. Medicine and Science in Sports and Exercise, 16, 529-38.
3. Byrnes, W.C and Clarkson. P. M (1986) Delayed onset muscle soreness and training. Clinic in Sports Medicine, 5, 605-614.
4. Gulick DT, Kimura IF. Delayed onset muscle soreness: what is related DOMS research may serve to benefit a wider it and how do we treat it? J Sport Rehab 1996; 5: 234-43.
5. Safran MR, scaber AV, Garette JWE, warm up and muscular injury prevention, an update. Sports Med 1989;8 (4): 239-49.
6. Schwane, J.A, Johnson, S.R., Vandenakker, C.B and Armstrong, R.B (1983). Delayed onset muscular soreness and plasma CPK and LOH activities after downhill running. Medicine and Science in Sports and Exercise, 15, 51-6.
7. Clarkson, P.M., Apple, F.S., Byrnes, W.C., Mc Cornick, K>M and Triffletti. P (1986 a). Creatine Kinase Isoforms following isometric exercise. Muscle and Nerve, 10, 41-4.
8. Clarkson, P.M. Byrnes, W.C, Mc cormick, K.M. Turcotte L.P. and white, J. s (1986b) . Muscle soreness and serum creatine kinease activity following isometric, eccentric and concentric exercise. International Journal of Sports Medicine, 7,152-5.
9. Alexander Humphries, Srdjan Cirovic, Anthony M.J. Bull, Anthony Hearnden, Aliah F. Shaheen. 2015. Assessment of the glenohumeral joint's active and passive axial rotational range. Journal of Shoulder and Elbow Surgery 24:12, 1974-1981.
10. Friden, J, Sjostron M. and Ekblom B. (1983a) myofibrillar damage following intense eccentric exercise in man.
11. Griffin, J. E. and T. C. Karselis. Physical Agents for Physical Therapists, 2nd Ed. Springfield, IL: Charles C. Thomas, 1982, pp. 299-301.
12. Spiker, J. C. Ultrasound. In: Therapeutic Modalities in Sports Medicine, W. E. Prentice (Ed.). St. Louis: Times Mirror/Mosby College Publishing, 1986, pp. 119-135.
13. Zisken, M. C. and S. L. Michlovitz. Therapeutic ultrasound. In: Thermal Agents in Rehabilitation, S. L. MichIovitz (Ed.). Philadelphia: F.A. Davis Company, 1986, pp. 141-176.
14. Dinno MA, Crum LA, Wu I: The effect of therapeutic ultrasound on electrophysiological parameters of frog skin. Ultrasound Med Biol l5:46 1-470, 1989.
15. Lota MI, Darling RC: Changes in permeability of the red blood cell membrane in a homogeneous ultra sonic field. Arch Phys Med Rehabil 26:282-287, 1955.
16. Ann M. Cools, Dorien Borms, Birgit Castelein, Fran Vanderstukken, Fredrik R. Johansson. 2016. Evidence-based rehabilitation of athletes with glenohumeral instability. Knee Surgery, Sports Traumatology, Arthroscopy 24:2, 382-389.
17. Heather K. Vincent, Kevin R. Vincent. 2018. Cross Body Stretching for Internal Rotation Deficit. Current Sports Medicine Reports 17:3, 82.
18. Brancaccio P, Limongelli FM, Maffulli N. Monitoring of serum enzymes in sport. British Journal of Sports Medicine. 2006;40(2):96–7.
19. WMA. World Medical Association. World Medical Association Declaration of Helsinki Ethical Principles for Medical Research Involving Human Subjects. Journal International de Bioéthique 2013;10(20):219.
20. Hyer JM, Waller JL. Comparison of Five Analytic Techniques for Two-Group, Pre-Post Repeated Measures Designs Using SAS. SAS Global Forum 2014 Proceedings 2014;1–8.
21. Julious SA (2005). sample size. Sample size of 12 per group rule of thumb for a pilot study Pharmaceut Statist, 4: 287-291.
22. Stupka N, Lowther S, Chorneyko K, Bourgeois JM, Hogben C, Tarnopolsky MA. Gender differences in muscle inflammation after eccentric exercise. Journal of Applied Physiology 2000; 89(6): 2325–32.
23. Patino CM, Ferreira JC. Inclusion and exclusion criteria in research studies: definitions and why they matter. Jornal Brasileiro de Pneumologia 2018;44(2):84–84
24. Valtonen EJ: A comparative short-term trial with Voltaren (Diclofenac sodium) and naproxen in soft-tissue rheumatism. Scand J Rheumatol 1978; 7(suppl 22): 69 73.
25. Double-blind Study Comparing the Use of Voltaren Emulgel " versus Regular Gel During Ultrasonic Sessions in the Treatment of Localized Traumatic and Rheumatic Painful Conditions. 2015;219–27.
26. Hsieh Y. Effects of Ultrasound and Diclofenac Phonophoresis on Inflammatory Pain Relief : Suppression of Inducible Nitric Oxide Synthase in Arthritic Rats. 2006;86(1):39–49.
27. Kalaiselvan A, M K, M.V S. Effect of proprioceptive neuromuscular facilitation versus Muscle energy technique in improving muscle Function in delayed onset muscle soreness in recreational players. International Journal of Pharma and Bio Sciences 2017;8(3).
28. Santos Parrilla A. 1RM Prediction : a data mining case study. 2014;92.
29. Férard G, Franck PFH, Gella F, Hoelzel W, Jørgensen PJ, Kessner A, et al. IFCC Primary Reference Procedures for the Measurement of Catalytic Activity Concentrations of Enzymes at 37 ° C. 2002;40(6):635–42.
30. Johnson C, Monath TP, Kanesa-Thasan N, Mathis D, Miller C, Shapiro S, et al. Exercise-induced serum enzyme elevations confounding the evaluation of investigational drug toxicity. Report of two cases in a vaccine trial. Human Vaccines. 2005;1(1):24–9.
31. Personal M, Archive R, Mohajan H, Mohajan HK. M P RA Two Criteria for Good Measurements in Research: Validity and Reliability Two Criteria for Good Measurements in Research: Validity and Reliability. 2017;(17):56-82.
32. Smith LL. Causes of delayed onset muscle soreness and the impact on athletic performance: a review. J Appl Sport Sci Res 1992; 6 (3): 135-41.
33. Orchard J, Marsden J, Lord S, et al. Pre-season hamstring muscle weakness associated with hamstring muscle injury in Australian footballers. Am J Sports Med 1997; 25 (1): 81-5.
34. Asmussen, E., 1956 'Observations on experimental muscle soreness". Acta Rheum. Scand. 2: 109-116.
35. Hasson SM, Daniels JC, Divine JG, et al. , Effect of ibuprofen use on muscle soreness, damage, and performance: a preliminary investigation. Med Sci Sports Exerc 1993; 25 (1): 9-17.
36. L. M. Brewster, G. Mairuhu, N. R. Bindraban, R. P. Koopmans, J. F. Clark, and G. A. Van Montfrans, “Creatine kinase activity is associated with blood pressure,” Circulation, vol. 114, no. 19,pp. 2034–2039, 2006.