Author(s):
Y. E. Matiichuk, T. I. Chaban, V. V. Ogurtsov, I. G. Chaban, V. S. Matiychuk
Email(s):
v_matiychuk@ukr.net
DOI:
10.5958/0974-360X.2020.00653.8 
Address:
Y. E. Matiichuk1, T. I. Chaban1, V. V. Ogurtsov1, I. G. Chaban2, V. S. Matiychuk3
1Department of General, Bioinorganic, Physical and Colloidal Chemistry, Danylo Halytsky Lviv National Medical University, 69 Pekarska, Lviv, 79010, Ukraine
2Department of Pharmaceutical Chemistry FPGE, Danylo Halytsky Lviv National Medical University,
69 Pekarska, Lviv, 79010, Ukraine
3Department of Organic Chemistry, Ivan Franko National University of Lviv, 6 Kyrylaі Mefodia,
Lviv, 79005, Ukraine
*Corresponding Author
Published In:
Volume - 13,
Issue - 8,
Year - 2020
ABSTRACT:
The synthesis and antitumor activity determination of some novel 2-(1H-benzoimidazol-2-yland 2-benzothiazol-2-yl)-3-(5-phenylfuran-2-yl)-acrylonitrilesderivatives are described. By the reaction of 5–arylfurfurals with 1H-benzimidazol-2-yl) acetonitrile, benzthiazol-2-ylacetonitrile and (4-arylthiazol-2-yl)-acetonitrile were synthesed 3-(5-arylfuran-2-yl)acrylonitrile derivatives. The structure of synthesized compounds was confirmed by elemental analysis and 1H NMR spectroscopy. Within the framework of the International Research Program DTP (Developmental Therapeutic Program) of the National Cancer Institute's (NCI, Betezda, Merilend, USA) antitumor activity screening of synthesized compounds was carried out. It was established that these compounds are promising to search as anti-cancer agents.
Cite this article:
Y. E. Matiichuk, T. I. Chaban, V. V. Ogurtsov, I. G. Chaban, V. S. Matiychuk. Antitumor Properties of Novel 2-(1H-Benzoimidazol-2-yland 2-Benzothiazol-2-yl)-3-(5-phenylfuran-2-yl)-acrylonitriles Derivatives. Research J. Pharm. and Tech. 2020; 13(8):3690-3696. doi: 10.5958/0974-360X.2020.00653.8
Cite(Electronic):
Y. E. Matiichuk, T. I. Chaban, V. V. Ogurtsov, I. G. Chaban, V. S. Matiychuk. Antitumor Properties of Novel 2-(1H-Benzoimidazol-2-yland 2-Benzothiazol-2-yl)-3-(5-phenylfuran-2-yl)-acrylonitriles Derivatives. Research J. Pharm. and Tech. 2020; 13(8):3690-3696. doi: 10.5958/0974-360X.2020.00653.8 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2020-13-8-23
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