Author(s): Om M. Bagade, Shashikant N. Dhole, Praveen D. Chaudhari

Email(s): ombagadescop@gmail.com

DOI: 10.5958/0974-360X.2020.00792.1   

Address: Om M. Bagade1*, Shashikant N. Dhole2, Praveen D. Chaudhari1
1Department of Pharmaceutics, PES Modern College of Pharmacy, Yamuna Nagar, Nigdi, Pune 411044 Maharashtra India.
2Department of Pharmaceutics, PES Modern College of Pharmacy, Moshi, Pune 412105 Maharashtra India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 9,     Year - 2020


ABSTRACT:
Nanosponges are tiny sponges with a size of a small virus, which can be filled with a wide variety of drugs and can circulate around the body until they stumble upon the specific target site and attach on the surface and begin to release the drug in a controlled and expected manner. Praziquantel is anthelmintic drug which is belong to biopharmaceutical class II drug. There was no interaction found between drug and excipients as revealed by an IR spectra and standard curve of the pure drug and placebo formulation. Nanosponge of different ratios were prepared by emulsion solvent diffusion method by using ethyl cellulose (X1) and PVA / whey protein was used as polymers, dichloromethane (DCM) (X2) as a solvent and Stirring speed (X3) maintained for different batches. These factors were selected as independent variables, while Drug loading, Particle size and cumulative drug release were selected as dependent variables. The whey protein is used as stabilizers. Furthermore, an optimal batch was selected from eight formulations by using 23factorial design and evaluated for bulk density, tapped density, angle of repose, compressibility Index, Carr’s index, dissolution studies, Entrapment efficiency, production yield, compatibility studies, powder x-ray diffraction (P-XRD), Differential scanning colorimetric (DSC), particle size analysis etc. Hence, nanosponge formulation using a variety of polymers was found to be a good alternative approach for increasing the dissolution rate of Praziquantel.


Cite this article:
Om M. Bagade, Shashikant N. Dhole, Praveen D. Chaudhari. An Influence of Lyophilization on Praziquantel Loaded Nanosponge’s by using food protein as a stabilizer with effect of Statistical Optimization. Research J. Pharm. and Tech. 2020; 13(9):4491-4498. doi: 10.5958/0974-360X.2020.00792.1

Cite(Electronic):
Om M. Bagade, Shashikant N. Dhole, Praveen D. Chaudhari. An Influence of Lyophilization on Praziquantel Loaded Nanosponge’s by using food protein as a stabilizer with effect of Statistical Optimization. Research J. Pharm. and Tech. 2020; 13(9):4491-4498. doi: 10.5958/0974-360X.2020.00792.1   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2020-13-9-80


REFERENCES:
1.    Tripathi KD. Anthelmintics Drugs. Essential of medicinal pharmacology. 7:849-855.
2.    Geeta Y, Hiten P. Nanosponge: A Boon to The Targeted Drug Delivery System, Journal of Drug Delivery and Therapeutics. 2013; 3(4):151-155.
3.    Francesco T, Robert C. Characterization and Applications of New Hyper Cross - Linked Cyclodextrin. Composite Interfaces. 2009; 16:39-48.
4.    Jilsha G, Vidya V. Nanosponges loaded hydrogel of cephalexin for topical delivery. International journal of pharmaceutical science and research. 2015; 6 (7):2781-2789.
5.    Gursalkar T, Balaji A, Jain D. Cyclodextrin based nanosponges of pharmaceutical use: A Review. Acta pharm. 2013; 63: 335-358.
6.    Vyas S, Khar K. Targeted and Controlled Drug Delivery- Novel Carrier Systems. Molecular Basis of Targeted Drug Delivery. CBS Publishers and Distributors, New Delhi. 38- 40. 2008.
7.    Pravin S, Kiran D, Francesco T, Frabrizio C. Novel cyclodextrin Nanosponges for delivery of calcium in hyperphophetemia. International journal of pharmaceutics. 2013; 456:95-100.
8.    Monica R, Amrita B, Ishwar K, Ghanshyam M, Francesco T. In vitro and in vivo evaluation of b-cyclodextrin-based nanosponges of telmisartan. Journal of inclusion phenomenon and macrocyclic chemistry. 2012; 1-11.
9.    Khalid A, Pradeep V, Francesco T, Robert C. Cyclodextrin-Based Nanosponges for Delivery of Resveratrol: In Vitro Characterisation, Stability, Cytotoxicity and Permeation Study. American association of pharmaceutical scientist (AAPS) . 2011; 12(1):279-286.
10.    Shankar S, Pradeep V, Francesco T, Satyen T. Formulation of betacyclodextrin based nanosponges of itraconazole. Journal of inclusion phenomenon and macrocyclic chemistry. 2007; 57:89-94.
11.    Subramanian S, Singireddy A, Krishnamurthy K, and Rajappan M. Nanosponges: A Novel Class of Drug Delivery System-review; Journal of Pharm Pharmaceutical Science. 2012; 15(1):103-111.
12.    Bindiya P, Om B, Kuldeep R, Riddhi P, Varsha A. An assessment on preparations, characterization, and poles apart Appliances of nanosponge. International Journal of Pharm Tech Research. 2014;6(6):1898-1907.
13.    Raja N, Kiran K, Kotapati A. Fabrication and Evaluation of Ciprofloxacin Loaded Nanosponges for Sustained Release. International Journal of Research In Pharmaceutical And Nano Sciences. 2013;2(1): 1 - 9.
14.    Roberta C, Francesco T, Wander T.Cyclodextrin-based Nanosponges for Drug Delivery. Journal of inclusion phenomenon and macrocyclic chemistry. 2006; 56:209-213.
15.    Prathima S, Sreeja K. Formulation and Evaluation of Voriconazole Loaded Nanosponges for Oral and Topical Delivery. International Journal of Drug Development and Research. 2013; 5(1):55-69.
16.    Indira B, Bolisetti S, Samrat C, Reddy SM, Neerudu R. Nanosponges: A New Era in Drug Delivery: Review. Journal of Pharmacy Research. 2012; 5(12), 5293-5296.
17.    Naga J., Srinath N, Ramadevi B, Lakshmi S, Vinusha K, Renuka K. Nanosponges: A Versatile Drug Delivery System. International Journal of Pharmacy and Life Sciences. 2013; 4 (8):2920-2925.
18.    Krishnamurth K, M Rajappa. Nanosponges: A Novel Class of Drug Delivery System-Review. Journal of Pharmacy Pharmaceutical science. 2012; 15(1):11-15.
19.    Madhuri S, Alok M, Rishikesh G, Sunil P, Kuldeep B, Prashant K. Fabrication and characterization of nifedipine loaded β-cyclodextrin nanosponges: An in vitro and in vivo evaluation. Journal of Drug Delivery Science and Technology.2017; 1-19.
20.    Madhuri S, Sunil P, Alok M, Shashi A, Poonam Y, Amita V. Nanosponges: a potential nanocarrier for novel drug delivery-a review. Asian Pacific Journal of Tropical Disease. 2014; 519-526.
21.    Shankar S, Pradeep V, Francesco T, Roberta C, Simonetta T, Luca B, Salvatore C. Structural evidence of differential forms of nanosponges of beta-cyclodextrin and its effect on solubilization of a model drug. Journal of inclusion phenomenon and macrocyclic chemistry. 2012; 76:201-211.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available