Author(s): Zahraa Amer Al-Juboori, Zainab H. Mahdi, Anas Tarik Alhamdany

Email(s): zhmpharm@yahoo.com

DOI: 10.5958/0974-360X.2021.00017.2   

Address: Zahraa Amer Al-Juboori, Zainab H. Mahdi*, Anas Tarik Alhamdany
Department of Pharmaceutics, College of Pharmacy, Al- Mustansiriyah University, Baghdad, Iraq.
*Corresponding Author

Published In:   Volume - 14,      Issue - 1,     Year - 2021


ABSTRACT:
Ocular drug delivery was considered a challenging approach for many decades, due to the limitation in the bioavailability in addition to the common drawbacks of the conventional eye preparations represented with blurred vision, pre-corneal elimination and high variability. For this reason, six different ion- induced ocular in-situ gel were formulated containing combination of ciprofloxacin and naproxen using sodium alginate and gellan gum in three different concentrations (0.1, 0.3 and 0.5%) as ion cross-linking polymers in conjugation with HPMC as viscosity enhancer. These were characterized for clarity, pH and drug content, in addition to the evaluation of their in-situ gelling capacity and rheological properties. Moreover, in- vitro dissolution analysis and antimicrobial studies were performed to ensure the proper releases and the effectiveness of the formulas. The results revealed that all prepared formulas exhibited a clear, transparent appearance with acceptable pH and drug content. Furthermore, the prepared formula (F3) containing 0.5% sodium alginate was selected as the optimal formula, having best gelling capacity and viscosity which gives an ideal release profile for extended period up to 8 hours. Finally, the antimicrobial study proves the effectiveness of the prepared formula with greater zone of inhibition compared to the conventional ciprofloxacin eye drop. As a result, we can conclude the successful preparation of sustained release ocular in-situ gel of ciprofloxacin and naproxen that can be considered as an effective replacement to the available eye drops of both drugs which used to prevent bacterial infection and minimizing the inflammation followed the surgical operation of cataract.


Cite this article:
Zahraa Amer Al-Juboori, Zainab H. Mahdi, Anas Tarik Alhamdany. Formulation and Evaluation of Ocular in-Situ gelling system containing Ciprofloxacin and Naproxen Sodium. Research J. Pharm. and Tech. 2021; 14(1):91-95. doi: 10.5958/0974-360X.2021.00017.2

Cite(Electronic):
Zahraa Amer Al-Juboori, Zainab H. Mahdi, Anas Tarik Alhamdany. Formulation and Evaluation of Ocular in-Situ gelling system containing Ciprofloxacin and Naproxen Sodium. Research J. Pharm. and Tech. 2021; 14(1):91-95. doi: 10.5958/0974-360X.2021.00017.2   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-1-17


REFERENCES:
1.    Bhagat BV, Hapse SA, Mane AR, Pagar HJ, Wagh VS. Development of ophthalmic in situ gelling formulation of ciprofloxacin hydrochloride using gellan gum. Research Journal of Pharmacy and Technology. 2011; 4(11):1742-1745.
2.    Jayant D, Shah B, Anil B. Design and development of pH-monitored in situ gel of lomefloxacin. Journal of Pharmaceutical Science and Bioscientific Research. 2013;3(2):10-15.
3.    Harsha Vardhani Kondepati, Girish Pai Kulyadi, Vamshi Krishna Tippavajhala. A Review on In Situ gel forming ophthalmic drug delivery systems. Research J. Pharm. and Tech. 2018; 11(1): 380-386.
4.    Choudhary NG, Syed AM, Kale VV, Avari JG. Oral sustained release in situ gel forming polymeric drug delivery systems. Research Journal of Pharmacy and Technology. 2010; 3 (3): 682-687.
5.    Swapnil D, Sonawane, Swaroop L. Design and evaluation of ion induced in situ gel formulation for levofloxacin hemihydrateocular delivery. International Journal of Pharmaceutical Science Invention. 2014;3(3):38-43.
6.    Prerana V, Asmita S, Sudha R. Microspheric in-situ gel for ocular drug delivery system of bromfenac sodium. International Journal of Pharmaceutical Sciences and Research. 2014;5(3):179-185.
7.    Nisha G Shetty and Charyulu RN. Phase transition ocular drug delivery system for antazoline phosphate. International Journal of Drug Formulation and Research. 2012;3(1);27-39.
8.    Baladaniya M, Vadgama N, Patel P. Gastro retentive in situ floating gel formulation – an overview. Research Journal of Pharmaceutical Dosage Forms andTechnology.2014;6(2):140-145.
9.    Tanvi PP, Moin KM, Vishnu MP. Sustained ophthalmic delivery of ciprofloxacin hydrochloride from an ion-activated in situ gelling system. Der Pharmacia Lettre. 2011;3(4):404-410.
10.    NS Malekar, SB Gondkar, RB Saudagar. In- situ nasal gel: a review. Research Journal of Pharmaceutical Dosage Forms and Technology. 2015; 7(4): 285-293.
11.    Prasanth VV, Della GT, Shashi R. Formulation and evaluation of in situ ocular gel of levofloxacin. Journal of Drug Delivery and Therapeutics. 2017; 7(4):68-73.
12.    Mahdi ZH, Maraie NK, Amer ZA. Application of liquisolid technology to enhance the dissolution of cefixime from its oral capsules. International Journal of Applied Pharmaceutics. 2018; 10(5): 214-219.
13.    Gupta SK, Singhvi IJ. In situ gelling system and other possible innovative approach for ocular disease: a review. Research Journal of Pharmacy and Technology. 2011; 4(6): 872-882.
14.    Sandeep DS, Narayana CR, Anoop NV. Smart in situ gels for glaucoma- an overview. International Journal of Pharmaceutical Sciences Review and Research. 2018;50(4):94-100.
15.    Mahdi ZH, Maraie NK. Overview on nanoemulsion as a recently developed approach in drug nanoformulation. Research Journal of Pharmacy and Technology. 2019; 12(11): 1-7.
16.    Makwana SB, Patel VA, Parmar SJ. Development and characterization of in-situ gel for ophthalmic formulation containing ciprofloxacin hydrochloride. Results in Pharma Sciences. 2016;6(2):1-6.
17.    Nazia K, Mohammed A, Ameeduzzafar, Syed SI, Asgar A. Development and evaluation of a novel in situ gel of sparfloxacin for sustained ocular drug delivery: in vitro and ex vivo characterization. Pharmaceutical Development and Technology.2019;9(3):1-8.
18.    Reeshanteni B, Abdullah K, Rajermani T. Formulation of in-situ gelling system for ophthalmic delivery of erythromycin. International Journal of Students Research in Technology and Management. 2017;5(1):1-8.
19.    Mundhada DR, Chandewar AV. An overview on in-situ gel. Research Journal of Pharmaceutical Dosage Forms and Technology. 2015; 7(4): 261-265.
20.    Sonjoy M, Manjunath KM, Thimmasetty J, Prabhushankar GL, Geetha MS. Formulation and evaluation of an in situ gel-forming ophthalmic formulation of moxifloxacin hydrochloride. International Journal of Pharmaceutical Investigation. 2012; 2(2): 78-82.
21.    Mudit D, Parthasarthi KK, Narayana C. Enhancing solubility and dissolution of naproxen by spray drying technique. World Journal of Pharmacy and Pharmaceutical Sciences. 2014; 4(1): 715-725.
22.    Gupta SK, Singhvi IJ. Sustained ophthalmic delivery of moxifloxacin hydrochloride from a pH triggered in situ gelling system. Research Journal of Pharmacy and Technology. 2012; 5(12):1538-1542.
23.    Gulecha BS, Shahi S, Lahoti SR. Floating in situ gelling drug delivery system of verapamil hydrochloride. American Journal of Pharm Tech Research. 2012; 2(4):954-969.
24.    Nagesh C, Manish P, Chandrashekhara S, Rahul S. A novel in situ gel for sustained ophthalmic delivery of ciprofloxacin hydrochloride and dexamethasone- design and characterization. Der Pharmacia Lettre. 2012; 4(3): 821-827.
25.    Vazir AA, Shiv Kumar HG, Paranjothy KLK, Mohd K. Ophthalmic drug delivery of diclofenac potassium from different polymer formulations: in situ sol gels. Research Journal of Pharmaceutical Dosage Forms and Technology. 2009; 1(2): 158-161.

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