Kishore Kamere, S.V Gopalakrishna, G.V. Subbareddy
Email ID Not Available
Kishore Kamere1*, S.V Gopalakrishna2, G.V. Subbareddy3
1Research Scholar, JNTUA, Anantapuramu, Andhra Pradesh, India.
2Vagdevi College of Pharmacy and Research Centre, Brahmadevam (V), Muthukur (M), Nellore Dt.-524 346, Andhra Pradesh, India.
3JNTUA College of Engineering, Pulivendula, YSR Kadapa Dt.-516390, Andhra Pradesh, India.
Volume - 14,
Issue - 1,
Year - 2021
The aim of present investigation was to develop efficient controlled release floating tablet (CRFT) of Repaglinide. Floating dosage form for gastric retention has potential to use as controlled-release drug delivery systems which providing opportunity for both local and systemic drug action. The tablets were prepared by using wet granulation techniques using PVP K 30, NKG and Carbopol 934 P. A 32 full factorial design (CCD) was applied to optimize two independent variables at three different levels by varied response variables. Two independent variables i.e. amount of NKG (i.e., polymer X1) and amount of Carbopol 934 P (i.e., polymer X2) were varied at three different levels that was coded for low, medium and high (-1, 0, 1 respectively). The response variables T6 (cumulative % amount of drug released in 6 hr) (Y1), T12 (cumulative % amount of drug released in 12 hr) (Y2), Q50 (time in minutes required to 50% of drug released) (Y3), FLT (Y4), TFT (Y5), and Swelling Index after 12 hr (Y6) were selected for present study. ANOVA study was also employed to optimize for best fitted quadratic model. Compressed matrices exhibited Super case-II transport drug release kinetics approaching zero-order, as the value of release rate exponent (n) varied between 0.9430 and 1.0133. Formulation A4 was the optimized best formulation from the response surface plot and contour plot of all the formulation.
Cite this article:
Kishore Kamere, S.V Gopalakrishna, G.V. Subbareddy. Optimization of Repaglinide Controlled Release Floating Tablet. Research J. Pharm. and Tech. 2021; 14(1):109-114. doi: 10.5958/0974-360X.2021.00020.2
Kishore Kamere, S.V Gopalakrishna, G.V. Subbareddy. Optimization of Repaglinide Controlled Release Floating Tablet. Research J. Pharm. and Tech. 2021; 14(1):109-114. doi: 10.5958/0974-360X.2021.00020.2 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-1-20
1. Formulation and Evaluation of Antidiabetic Herbal Capsules. P. B. Suruse, M. K. Kale, N. J. Duragkar, A. Gundawar. Research J. Pharma. Dosage Forms and Tech. 2011; 4(2): 113-118.
2. Fares Hezam Al-Ostoot, Vidya, R., Zabiulla, Yasser Hussein Eissa Mohammed, Mahima Jyothi, Pallavi. H.M, Shaukath Ara Khanum. Statistical Analysis of Antimicrobial Data of 2-[2-(Aroyl) aroyloxy] methyl-1,3,4 Oxadiazoles analogues Using ANOVA. Asian J. Research Chem. 2018; 11(2):293-297.
3. Malaisse W. Repaglinide, a new oral anti-diabetic agent: a review of recent preclinical studies. Eur J Clin Invest. 1999; 29: 21-29.
4. Landgraf R, Frank M, Bauer C, Dieken M. Prandial glucose regulation with repaglinide: it’s clinical and lifestyle impact in a large cohort of patients with Type II diabetes. Int J Obesity. 2000; 24: S38-S44.
5. Saibaba, S.V.; Kumar, M.S.; Ramu, B. Pharmaceutical impurities and their characterization. European J Pharm Med Res 2016, 3(5), 190-196.
6. S Gopalakrishnan, A Chenthilnathan. Formulation and In Vitro evaluation of Aceclofenac oral floating tablets. Research J. Pharm. and Tech. 4(4): April 2011; Page 642-645.
7. Bandameedi R, Pandiyan PS. Formulation and evaluation of gastro retentive floating bioadhesive tablets of hydrochlorothiazide. Asian J Pharm Clin Res 2017;10: 150-5.
8. Addanki Gopikrishna, B. Ramu, G. Srikanth, Dr. Bigala Rajkamal (2016). Formulation of isoniazide sustained release formulation by using carbopol 934 PP. Int J App Pharm Sci Res. 1(2):60- 69. Doi: 10.21477/ijapsr.v1i2.10177.
9. Lachman L, Lieberman HA, Kanig JL. The Theory and Practice of Industrial Pharmacy. Varghese Publishing House, Bombay. 3rdedn. 1991, page no: 184.
10. Fares Hezam Al-Ostoot, Vidya, R., Zabiulla, Yasser Hussein Eissa Mohammed, Mahima Jyothi, Pallavi. H.M, Shaukath Ara Khanum. Statistical Analysis of Antimicrobial Data of 2-[2-(Aroyl)aroyloxy]methyl-1,3,4 Oxadiazoles analogues Using ANOVA. Asian J. Research Chem. 2018; 11(2):293-297.
11. Ravi K. Barde, Minal R. Narkhede, V.R. Gudsoorkar, Rahul K. Amrutkar, Prashant S. Walke. Formulation and Evaluation of Sustained Release Floating Matrix Tablets of Labetalol Hydrochloride. Research J. Pharm. and Tech. 4(10): Oct. 2011; Page 1637-1643
12. N. Utharalakshmi, A. Ganesh Kumar, G. Narendrakumar. Optimization of Cellulase Producing Aspergillus flavus SB4 by Solid State Fermentation using Response Surface Methodology (RSM)-CCD. Research J. Pharm. and Tech. 8(4): April, 2015; Page 349-354.
13. Vishnu Vardhana Rao. G, V. Srinivasa Rao, K. Ramakrishna. Quality by Design Approach for the Development and Validation of LC method for the Estimation of in-Vitro release of Raloxifene hydrochloride in Dosage Formulation. Research J. Pharm. and Tech. 8(11): Nov., 2015; Page 1487-1494.
14. P. Pandian, D. Kalpanapriya. Two-factor ANOVA Technique for Fuzzy Data having Membership Grades. Research J. Pharm. and Tech. 2016; 9(12): 2394-2402.
15. Varma MM, Suneetha S, Raju DB. Design and Evaluation of Floating Drug Delivery System of Furosemide. Research J. Pharm. and Tech. 3(2): April- June 2010; Page 452-454.
16. D.Anuradha D. Kalpanapriya. Intuitionistic Fuzzy ANOVA and its Application in Medical Diagnosis. Research J. Pharm. and Tech 2018; 11(2):653-656.
17. Kiran Deshpande, Pranjali Ranaware, A. R. Madgulkar, M.C. Damle. Development and Validation of Stability Indicating HPTLC Method for Determination of Repaglinide. Research J. Pharm. and Tech. 6(2): Feb. 2013; Page 158-161.
18. B. Sumalatha, D. John Babu, A. Venkatanarayana, P. Rajasekhar Reddy, P. Divya Sruthi. Experimental Investigation on Biosorption of Chromium from Aqueous Solution using Citrus limonium peel: Optimization of Process Parameters using Central Composite Design. Research J. Pharm. and Tech 2018; 11(12): 5253-5264.
19. Siddamsetty Upendra, Siddamsetty Mahendra, Poli Sivasankar Rao. Two-way ANOVA Calculations Using MS-Excel. Research J. Science and Tech. 2017; 9(4): 532-536.
20. Hyma Ponnaganti, Abbulu. K. Enhanced Dissolution of Repaglinide: SMEDDS Formulation and In-vitro Evaluation. Research J. Pharm. and Tech. 7(11): Nov. 2014 Page 1246-1252.
21. Sanjay Dey, Snigdha Dutta, Bhaskar Mazumder, “Formulation and evaluation of floating matrix tablet of atenolol for gastro-retentive drug delivery”, Int. J. of Pharm. and Pharm. Sci., 2013;4:433-437.
22. Pramod Patil, Someshwara Rao B, Suresh V Kulkarni, Basavaraj, Chetan Surpur, Anand Ammanage. Formulation and In Vitro Evaluation of Floating Matrix Tablets of Ofloxacin. Asian J. Res. Pharm. Sci. 1(1): Jan.-Mar. 2011; Page 17-22.
23. N. M. Vageesh, Ramya Sri Sura, K Gulijar Begum, B Swathi. Formulation Development and In vitro Evaluation of Floating Tablets of Lafutidine by Employing Effervescent Technology. Asian J. Pharm. Res. 2017; 7(3): 189-197.
24. Grassi M, Grassi G. Mathematical Modelling and Controlled Drug Delivery: Matrix Systems. Current Drug Delivery; 2005; 2:97-116.
25. http://www.anvpublication.org/Universal_Search.aspx?What=CitationList & tmp_PID= 191120201257988354.