Author(s):
Saravanakumar K., Durga Srinivasa Rao M., Kothapalli Bannoth Chandrasekhar
Email(s):
kumarpharmacy156@gmail.com
DOI:
10.5958/0974-360X.2021.00030.5 
Address:
Saravanakumar K.1*, Durga Srinivasa Rao M.2, Kothapalli Bannoth Chandrasekhar3
1Professor and Head, Dept. of Pharmaceutics, Sree Vidyanikethan College of Pharmacy, A. Rangampet, Sree Sainath Nagar, Tirupati-517102, Chittoor (Dist.), A.P., India.
2Research Scholar, Dept. of Pharmaceutical Sciences, JNTU Anantapur, Anantapur- 515002, A.P., India.
3Professor, Dept. of Chemistry and Director, Foreign Affairs and Alumni Matters, JNTU Anantapur, Anantapur- 515002, A.P., India.
*Corresponding Author
Published In:
Volume - 14,
Issue - 1,
Year - 2021
ABSTRACT:
Aim and Objectives: The aim of the current study is to study the effect of combination of synthetic and natural polymers in extending the release of Tolperisone HCl (TH) from its effervescent Floating Tablets (FT), which can extend its release up to 12 h. Methods: The drug- excipient compatibility studies of TH and the polymers used in the study were carried by FTIR studies. THFT were prepared by direct compression method. All batches were evaluated for pre-compression, post-compression and in vitro buoyancy studies. Accelerated stability studies were performed for the optimized formulation THFT11 as per ICH guidelines. Results and Discussion: The drug-excipient compatibility studies reveal that TH and the polymers used for the study are compatible. Pre- and post-compression parameters were within the acceptable limits for all formulations. In vitro dissolution studies showed the formulation THFT11 (6.25% w/w sodium alginate and 18.75% w/w HPMC K100M) had extended the release of TH up to 12 h, with a floating lag time (FLT) of 58 ± 0.71 sec, total floating time (TFT) and matrix integrity (MI) maintained up to 12 h, hence it is selected as an optimized one. In vitro drug release kinetics of optimized THFT11; suggests the drug release follows zero order profile (r2=0.988), drug release is predominantly by diffusion and the release mechanism is by super case-II transport. DSC and FT-IR studies of TH and accelerated stability samples of F11 further confirmed the drug is in the same state as pure TH. Accelerated stability studies of optimized THFT11; indicates it passes the test for stability as per ICH guidelines. Conclusion: Finally, it was concluded that an optimized effervescent THFT was formulated and evaluated with the combination of synthetic and natural polymers.
Cite this article:
Saravanakumar K., Durga Srinivasa Rao M., Kothapalli Bannoth Chandrasekhar. Combination Effect of Natural and Synthetic Polymers in Extending the Release of Tolperisone HCl from its Effervescent Floating Tablets. Research J. Pharm. and Tech. 2021; 14(1):171-178. doi: 10.5958/0974-360X.2021.00030.5
Cite(Electronic):
Saravanakumar K., Durga Srinivasa Rao M., Kothapalli Bannoth Chandrasekhar. Combination Effect of Natural and Synthetic Polymers in Extending the Release of Tolperisone HCl from its Effervescent Floating Tablets. Research J. Pharm. and Tech. 2021; 14(1):171-178. doi: 10.5958/0974-360X.2021.00030.5 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-1-30
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