Author(s): Deepika B, K. Sujatha, A. Thanga Thirupathi, D. Chamundeeswari

Email(s): sujamano73@gmail.com

DOI: 10.5958/0974-360X.2021.00043.3   

Address: Deepika B1, K. Sujatha2*, A. Thanga Thirupathi1, D. Chamundeeswari2
1Associate Professor, Department of Pharmaceutics, Nalanda College of Pharmacy, Nalgonda-508001.
2Professor, Faculty of Pharmacy, SRIHER, Porur, Chennai-600116.
3Professor and Head of the Department, Nalanda College of Pharmacy, Nalgonda-508001.
4Research Scholar, University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506009.
*Corresponding Author

Published In:   Volume - 14,      Issue - 1,     Year - 2021


ABSTRACT:
Currently, the use of natural gums and mucilage is of increasing importance in pharmaceutical formulations. Natural plant-based materials are economic, free of side effects, biocompatible and biodegradable. In this research, Miglitol Matrix tablets were formulated using Natural Gum extract of Hibiscus rosa sinensis leaves. Miglitol is an antidiabetic drug with less biological half-life of 1.5 hours. The objective behind the research was to delay the Miglitol drug release by matrix formation and allow the drug to get absorbed completely from the intestinal mucosa by using different concentrations of Hibiscus rosa sinensis leaves mucilage. Total four formulations were developed using different mucilage concentrations like 10%, 20%, 30% and 40% w/w. The tablets were prepared by using wet granulation technique and they were evaluated for physicochemical properties like weight variation, friability, hardness, thickness and in vitro drug release. The dissolution studies indicated that the drug release from formulations was sustained up to 18 to 24 hours. The results concluded that the matrix formation in tablets containing 30% w/w of mucilage (optimized formulation) was high and the drug release was extended up to 24 hours. The dissolution data was well fitted into all kinetic models and the drug release data of optimized formulation was well fitted with zero order model and Higuchi equation indicating constant rate-diffusion controlled drug release. This research revealed the importance of a novel natural rate controlling mucilage in the formulation of sustained release matrix formulations.


Cite this article:
Deepika B, K. Sujatha, A. Thanga Thirupathi, D. Chamundeeswari. Formulation and Evaluation of Miglitol matrix tablets by using Hibiscus rosa sinensis leaves Mucilage. Research J. Pharm. and Tech. 2021; 14(1):245-248. doi: 10.5958/0974-360X.2021.00043.3

Cite(Electronic):
Deepika B, K. Sujatha, A. Thanga Thirupathi, D. Chamundeeswari. Formulation and Evaluation of Miglitol matrix tablets by using Hibiscus rosa sinensis leaves Mucilage. Research J. Pharm. and Tech. 2021; 14(1):245-248. doi: 10.5958/0974-360X.2021.00043.3   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-1-43


REFERENCES:
1.    MP SC, Prasobh GR, Jaghatha T, Aswathy BS, Remya SB. An Overview on Liposomal Drug Delivery System. Int. J. Pharm. Phytopharm. Res. 2019; 9(2):61-8.
2.    Nourmohammadi E, Nedaeinia R, Goli M, Hosseini Teshnizi S, Sarkarizi H, Sarkarizi K, Nedaeinia M, Faraji H. Novel application of Nanotechnology in drug and Gene delivery: emphasis on Liposomes. Int. J. Pharm. Phytopharm. Res. 2018; 8(6):81-91.
3.    Chauhan M, Jain A, Singh S, Chaurasiya K. Formulation and evaluation of sustained-release. World Journal of Pharmacy and Pharmaceutical Sciences, 2015 ;11:1194-1205.
4.    Sonone SB, Kokane SP, Shirote PJ, Naikawade NS. Controlled release matrix tablet formulation using synthesized N-acyl Thiolated Chitosan derivatives. Arab J Chem, 2015; 36: 0-4.
5.    Kimlek T, Prasertporn T, Sawantranon J, Sriwichupong C, Ritthidej G. Controlled release tablets of verapamil hydrochloride. Asian J Pharm Sci, 2016; 11: 219-220.
6.    Karuppusamy C, Venkatesan P. Preformulation Parameters Characterization to Design, Development, and Formulation of Miglitol Loaded Nanoparticles. Journal of Pharmaceutical Sciences and Research, 2017; 9: 326-331.
7.    Kaleemullah M, Jiyauddin K, Thiban E, Rasha S, Al-dhalli S. Development and evaluation of Ketoprofen sustained release matrix tablet using Hibiscus rosa-sinensis leaves mucilage. Saudi Pharm J 2017; 25: 770-779.
8.    Kumar AB, Umashankar MS, Porselvi A. Case Report on Dilated Cardiomyopathy in Type 2 Diabetes Mellitus Patient with Hypothyroidism. J. Adv. Pharm. Educ. Res. 2018; 8(2):1-4.
9.    Yadav N, Panwar MS. Formulation and evaluation of matrix tablets of miglitol using different grades of HPMC. Asian Journal of Pharmaceutics 2014; 12: 237-240.
10.    Ashtamkar, J., Nangude, S. Formulation and evaluation of controlled release tablets of miglitol. International Journal of Pharmaceutical Sciences and Research 2013; 4: 1833-1837.
11.    Fukui S, Yano H, Yada S, Mikkaichi T. Design and evaluation of an extended-release matrix tablet formulation ; the combination of hypromellose acetate succinate and hydroxypropyl cellulose. Asian J Pharm Sci 2017; 12: 149-156.
12.    Group B, Campus I, Dist RR. Journal of Chemical and Pharmaceutical Research 2015: 7: 1213-1224.
13.    El-bagory I, Barakat N, Ibrahim MA. Formulation and in vitro evaluation of theophylline matrix tablets prepared by direct compression : Effect of polymer blends. Saudi Pharm J 2012; 20: 229-238.
14.    Krishnaraj K, Joghi M, Chandrasekar N, Joghi M, Muralidharan S, Manikandan D. Development of sustained-release antipsychotic tablets using novel polysaccharide isolated from Delonix regia seeds and its pharmacokinetic studies. Saudi Pharm J. 2012; 20: 239-248.
15.    Kumar G. Formulation Development and Evaluation of Sustained Release Matrix Tablets of Vildagliptin - Synthetic and Natural Polymers. Saudi Pharmaceutical Journal 2015; 2015: 5-11.
16.    Abdel-Rahman SI, Mahrous GM, El-badry M. Preparation and comparative evaluation of sustained-release metoclopramide hydrochloride matrix tablets. Saudi Pharm J 2009; 17: 283-288.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank

Journal Policies & Information


Recent Articles




Tags


Not Available