Author(s): Deepika B, K. Sujatha, A. Thanga Thirupathi, D. Chamundeeswari


DOI: 10.5958/0974-360X.2021.00043.3   

Address: Deepika B1, K. Sujatha2*, A. Thanga Thirupathi1, D. Chamundeeswari2
1Associate Professor, Department of Pharmaceutics, Nalanda College of Pharmacy, Nalgonda-508001.
2Professor, Faculty of Pharmacy, SRIHER, Porur, Chennai-600116.
3Professor and Head of the Department, Nalanda College of Pharmacy, Nalgonda-508001.
4Research Scholar, University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506009.
*Corresponding Author

Published In:   Volume - 14,      Issue - 1,     Year - 2021

Currently, the use of natural gums and mucilage is of increasing importance in pharmaceutical formulations. Natural plant-based materials are economic, free of side effects, biocompatible and biodegradable. In this research, Miglitol Matrix tablets were formulated using Natural Gum extract of Hibiscus rosa sinensis leaves. Miglitol is an antidiabetic drug with less biological half-life of 1.5 hours. The objective behind the research was to delay the Miglitol drug release by matrix formation and allow the drug to get absorbed completely from the intestinal mucosa by using different concentrations of Hibiscus rosa sinensis leaves mucilage. Total four formulations were developed using different mucilage concentrations like 10%, 20%, 30% and 40% w/w. The tablets were prepared by using wet granulation technique and they were evaluated for physicochemical properties like weight variation, friability, hardness, thickness and in vitro drug release. The dissolution studies indicated that the drug release from formulations was sustained up to 18 to 24 hours. The results concluded that the matrix formation in tablets containing 30% w/w of mucilage (optimized formulation) was high and the drug release was extended up to 24 hours. The dissolution data was well fitted into all kinetic models and the drug release data of optimized formulation was well fitted with zero order model and Higuchi equation indicating constant rate-diffusion controlled drug release. This research revealed the importance of a novel natural rate controlling mucilage in the formulation of sustained release matrix formulations.

Cite this article:
Deepika B, K. Sujatha, A. Thanga Thirupathi, D. Chamundeeswari. Formulation and Evaluation of Miglitol matrix tablets by using Hibiscus rosa sinensis leaves Mucilage. Research J. Pharm. and Tech. 2021; 14(1):245-248. doi: 10.5958/0974-360X.2021.00043.3

Deepika B, K. Sujatha, A. Thanga Thirupathi, D. Chamundeeswari. Formulation and Evaluation of Miglitol matrix tablets by using Hibiscus rosa sinensis leaves Mucilage. Research J. Pharm. and Tech. 2021; 14(1):245-248. doi: 10.5958/0974-360X.2021.00043.3   Available on:

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