Author(s):
Ulfatun Nisa, Peristiwan R Widhi Astana, Hadi Kuncoro
Email(s):
redfa01@gmail.com
DOI:
10.5958/0974-360X.2021.00045.7 
Address:
Ulfatun Nisa1, Peristiwan R Widhi Astana1, Hadi Kuncoro2
1Traditional Plant and Traditional Medicine Research and Development, National Institute Health Research and Development, Ministry of Health Republic of Indonesia.
2Faculty of Pharmacy, University of Mulawarman, Samarinda, Indonesia.
*Corresponding Author
Published In:
Volume - 14,
Issue - 1,
Year - 2021
ABSTRACT:
The objective of the study was to determine the effect of herb formula consisting of Syzygium polianthum leaves, Centella asiatica leaves, Imperata cylindrica roots, Myristica fragrans seeds, Curcuma xanthorizza rhizomes, Curcuma longa rhizomes and Phyllanthus niruri herbson serum uric acid levels of patients with mild hypertension. This research method was a quasi-experimental study with pre-post control design, noncomparative, conducted at clinical of saintification of jamu Hortus Medicus over 8 weeks. As much as 60 volunteers-fulfilling the inclusion and exclusion criteria were recruited as subjects. Serum uric acid level, renal and liver function were calculated at baseline, middle and end of study (at the end 8 weeks). There was a statistically significant difference between mean serum uric acid level at baseline and the end of treatment on mild hypertensive patients with hyperuricemic, which had a p-value < 0.05 (p = 0.023 (CI 95% 0.15-1.64)). Nevertheless. the number of subjects with hyperuricemia increased from 21.6% to 23.3%. at day 56. This study concludes that the antihypertensive formula is more favorable in lowering serum uric acid levels in mild hypertensive patients which had hyperuricemia.
Cite this article:
Ulfatun Nisa, Peristiwan R Widhi Astana, Hadi Kuncoro. The effect of Antihypertensive Herb formula of Indonesian traditional medicines against serum uric acid levels in mild Hypertensive patients. Research J. Pharm. and Tech. 2021; 14(1):254-258. doi: 10.5958/0974-360X.2021.00045.7
Cite(Electronic):
Ulfatun Nisa, Peristiwan R Widhi Astana, Hadi Kuncoro. The effect of Antihypertensive Herb formula of Indonesian traditional medicines against serum uric acid levels in mild Hypertensive patients. Research J. Pharm. and Tech. 2021; 14(1):254-258. doi: 10.5958/0974-360X.2021.00045.7 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-1-45
REFERENCE:
1. Archana S, Ram M. A Prospective Study on Assessment of Medication Adherence of Patients Towards Antihypertensive Medications. Res J Pharm Technol. 2017;10(11):3779–82.
2. Yeswanthi S, Jayakumari S. A Prospective Study on Combinational Drug Efficacy in Hypertensive Patients. Res J Pharm Technol. 2018;11(2):509–12.
3. Li W, Huang Y, Feng Y. Serum uric acid concentration is associated with ascending aortic dilatation in newly diagnosed nondiabetic hypertensive patients. Clin Exp Hypertens. 2019;1–6.
4. Kuwabara M. Hyperuricemia, Cardiovascular Disease, and Hypertension. Pulse. 2016;3(3–4):242–52.
5. Kuwabara M, Niwa K, Nishi Y, Mizuno A, Asano T, Masuda K, et al. Relationship between serum uric acid levels and hypertension among Japanese individuals not treated for hyperuricemia and hypertension. Hypertens Res. 2014;37(8):785–9.
6. Raina S, Agarwal VK, Kapoor D, Sharma KN, Yadav RS. Hypertension as determinant of hyperuricemia: A case control study from the sub-Himalayan region in north India. J Assoc Physicians India. 2018;66: 14–8.
7. Mukhopadhyay P, Ghosh S, Pandit K, Chatterjee P, Majhi B. Uric Acid and Its Correlation with Various Metabolic Parameters: A Population-Based Study. Indian J Endocrinol Metab. 2019;23(1):134–9.
8. Mansur SN, Watania FE, Surachmanto E. Hubungan Antara Kadar Asam Urat dengan Tekanan Darah pada Mahasiswa Pria Obesitas Sentral Fakultas Kedokteran Universitas Sam Ratulagi Manado. Exp Clin Cardiol. 2015;3(1):381–7.
9. Ngestiningsih D, Hadi S. Ekstrak Herbal (Daun Salam, Jintan Hitam, Daun Seledri) dan Kadar IL-6 Plasma Penderita Hiperurisemia. Mater Med Indones. 2011;45(2):113–7.
10. Hyperuricemia W, Randomized HAP, Gunawardhana L, Mclean L, Punzi HA, Hunt B, et al. Effect of Febuxostat on Ambulatory Blood Pressure in Subjects. Am Hear Assoc. 2017;6.
11. Zhao J, Dong P, Jia J, Zhao D, Wang H, Li D, et al. Allopurinol to influence blood pressure in hypertension patients: systematic review and meta-analysis. Int J Clin Exp Med. 2018;11(3):1390–400.
12. Liu J, Wang K, Liu H, Zhao H, Zhao X, Lan Y, et al. Relationship between carotid-femoral pulse wave velocity and uric acid in subjects with hypertension and hyperuricemia. Endocr J. 2019;66(7):629–36.
13. Kuwabara M, Niwa K, Hisatome I, Nakagawa T, Roncal-jimenez CA, Andres-hernando A, et al. Epidemiology / Population Asymptomatic Hyperuricemia Without Comorbidities Predicts Cardiometabolic Diseases Five-Year Japanese Cohort Study. Hypertension. 2017;69: 1036–44.
14. Phf G, Erdm S. Pharmacotherapy for hyperuricemia in hypertensive patients (Review). Cohrane Database Syst Rev. 2017;(4).
15. Kalita S, Kumar G, Karthik L, Venkata K, Rao B. A Review on Medicinal Properties of Lantana camara Linn. Res J Pharm Technol. 2012;5(6):711–5.
16. Venkataraman S, Harinya S, Chidiuto DB, Raja RR, Jasmine EN, Jasmine C. Phytochemical Constituents and Pharmacological Activities of Nyctanthes arbor-tristis. Res J Pharm Technol. 2019;12(10):4639–43.
17. Elfahmi, Woerdenbag HJ, Kayser O. Jamu: Indonesian traditional herbal medicine towards rational phytopharmacological use. J Herb Med. 2014;4(2):51–73.
18. Nisa U, Fitriani U, Wijayanti E. Aktivitas Ramuan Daun Salam, Herba Pegagan , Akar Alang-Alang dan Biji Pala pada Tikus Hipertensi yang Diinduksi Prednison dan Garam. J Kefarmasian Indones. 2017;7(2):87–94.
19. Sinaga AF, Bodhi W, Lolo Widya Astuti. Uji Efek Ekstrak Etanol Daun Salam (Syzygium polyanthum (wight) Walp) terhadap penurunan kadar asam urat diinduksi potasium oksonat. Pharmacon. 2014;3(2):141–5.
20. Kusuma A Mahardian, Wahyuningrum R, Wisyati T. Aktivitas Antihiperurisemia Ekstrak Etanol Herba Pegagan Pada Mencit Jantan Dengan Induksi Kafein. Pharmacy. 2014;11(1):62–74.
21. Umami R. Hubungan Antara Peningkatan Kadar Asam Urat Darah Dengan Kejadian Hipertensi di RSUD Sukoharjo. 2015.
22. Cheng W, Wen S, Wang Y, Qian Z, Tan Y, Li H, et al. The association between serum uric acid and blood pressure in different age groups in a healthy Chinese cohort. Medicine. 2017;50.
23. Novitasari A, Tatius B. Hiperuresemia Meningkatkan Risiko Hipertensi Hiperuresemia Increases Risk of Hypertension. Univ Muhammadiyah Semarang. 2014; 2025:1–7.
24. Yadav D, Lee ES, Kim HM, Lee EY, Choi E, Chung CH. Hyperuricemia as a Potential Determinant of Metabolic Syndrome. J lifestyle Med. 2013;3(2):98–106.
25. El R, Tallima H. Physiological functions and pathogenic potential of uric acid: A review. J Adv Res. 2017;8(5):487–93.
26. Bove M, Cicero AFG, Borghi C. The Effect of Xanthine Oxidase Inhibitors on Blood Pressure and Renal Function. Curr Hypertens Rep. 2017;19.
27. Liu C, He C, Chen N, Wang D, Shi X, Liu Y. Serum uric acid is independently and linearly associated with risk of nonalcoholic fatty liver disease in obese Chinese adults. Nat Publ Gr. 2016; 6:1–10.
28. Krishnaveni J, Ananthi T. Hepatoprotective Effect of Moringa oleifera in Isoniazid Induced Rats. Res J Pharm Technol. 2011;4(12):1901–3.
29. Manokaran S, Jaswanth A, Sengottuvelu S, Nandhakumar J, Duraisamy R, Karthikeyan D, et al. Hepatoprotective Activity of Aerva lanata Linn. Against Paracetamol Induced Hepatotoxicity in Rats. Res J Pharm Technol. 2008;1(4):398–400.
30. Agarwal V, Hans N, Messerli FH. Effect of Allopurinol on Blood Pressure: A Systematic Review. J Clin Hypertens. 2013;15 (6):435–42.
31. Sumathy P, Shanmugasundaram P, Monika M. A Prospective Study on Comparative Efficacy Between Two Combinational Therapies for Hypertension. Res J Pharm Technol. 2016;9(11):2005–8.
32. Saul S. Effects of Nyctanthes Arbor-Tristis and Colchicine on the Growth of Uric Acid Crystals. Asian J Pharm Anal. 2017;7(2):84–6.
33. Tiwaskar M. Hypertension and Hyperuricemia: A Compelling Correlation. J Assoc Physicians India. 2018;66: 11–2.
34. Whelton A. Hyperuricemia and hypertension: A confluence of concepts. Hypertension. 2012;60(5):1112–3.
35. Gupta AK, Gaur S, Kumar S. Descriptions, Ethnobotany and Diuretic activity of Indian medicinal plants. J Sci Innov Res. 2013;2(1).
36. Julius A, Renugadevi K, Hemavathy V. Effect of Oxidative Stress in Essential Hypertension. Res J Pharm Technol. 2014;7(12):1400–3.
37. Hameed IH, Ro M, Hadi MY. A Review: Solanum nigrum L. Antimicrobial, Antioxidant properties, Hepatoprotective effects and Analysis of Bioactive Natural Compounds. Res J Pharm Technol. 2017;10(11):4063–8.