Author(s):
Shradha Pandey, Prateek Pandey, Singh Shekhar Gautam, Jagdamba Singh
Email(s):
shradha.06@gmail.com
DOI:
10.5958/0974-360X.2021.00049.4 
Address:
Shradha Pandey1*, Prateek Pandey2, Singh Shekhar Gautam2, Jagdamba Singh1
1Environmentally Benign Laboratory, Dept. of Chemistry, University of Allahabad, Allahabad, Uttar Pradesh, India.
2United Institute of Pharmacy, Naini, Allahabad, Uttar Pradesh, India.
*Corresponding Author
Published In:
Volume - 14,
Issue - 1,
Year - 2021
ABSTRACT:
Pyrimidine and its thione derivatives have found a wide range of application in medicine due to their pronounced biological activity. An attempt has been made to combine the toxophoric qualities of biologically versatile 2-amino-4-aryl thiazole and 5-arylidene-3-aryl rhodanine moieties and synthesizing pyrimidin-2-thione derivatives, VII(a-j). The compounds were screened for their in vitro antifungal potential against Aspergillus niger and Fusarium oxysporium. The results were promising as the compounds VII b, VII c, VII g and VII h displayed fungicidal action equivalent to that of commercial fungicide Dithane M-45 at 1000 ppm concentration.
Cite this article:
Shradha Pandey, Prateek Pandey, Singh Shekhar Gautam, Jagdamba Singh. Synthesis, Characterization and Antifungal Evaluation of substituted Pyrimidin-2-thione Derivatives. Research J. Pharm. and Tech. 2021; 14(1):275-279. doi: 10.5958/0974-360X.2021.00049.4
Cite(Electronic):
Shradha Pandey, Prateek Pandey, Singh Shekhar Gautam, Jagdamba Singh. Synthesis, Characterization and Antifungal Evaluation of substituted Pyrimidin-2-thione Derivatives. Research J. Pharm. and Tech. 2021; 14(1):275-279. doi: 10.5958/0974-360X.2021.00049.4 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-1-49
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