Author(s):
J. Padmavathy, T. Venkatachalam, I. Sarath Chandiran, S. G. Raman, R. Rajkumar, D. Saravanan
Email(s):
dev.srvana@gmail.com
DOI:
10.5958/0974-360X.2021.00009.3 
Address:
J. Padmavathy1, T. Venkatachalam2, I. Sarath Chandiran3, S. G. Raman3, R. Rajkumar4, D. Saravanan5*
1School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, Tamil Nadu - 600117.
2Annai JKK Sampoorn Ammal College of Pharmacy, Komarapalayam, Namakkal, District, Tamil Nadu - 638183.
3School of Pharmacy, Sri Balaji Vidyapeeth Deemed to be University, Puducherry - 607402.
4Kamalakshi Pandurangan College of Pharmacy, Ayyampalayam, Thiruvannamalai, Tamil Nadu, India-606603.
5Jaya College of Paramedical Sciences, College of Pharmacy, CTH Road, Thiruninravur, Chennai, Tamil Nadu, India-602024.
*Corresponding Author
Published In:
Volume - 14,
Issue - 1,
Year - 2021
ABSTRACT:
The present study was carried out to find out the in-vivo anti-inflammatory and anti-diabetic activities of ethanol extract (200 and 400mg/kg) of leaves of Actinodaphne madraspatana (A. madraspatana) on Swiss Albino rats. The anti-inflammatory activity was investigated in carrageenan induced rat paw edema model which was compared with standard drug indomethacin at a dose level of 10mg/kg and the parameter measured being the paw volume by mercury displacements at 0, 15, 30, 60, and 120 minutes. The edema was induced in rats by administration of 1 % w/v solution of carrageenan in normal saline solution (1%w/v). The anti-diabetic activity was investigated in streptozotocin induced diabetic rat, which was compared with standard drug glibenclamide at a dose level of 4 mg/kg and the parameter measured being the blood glucose level on 0, 7, 14, 21 days. Diabetes was induced in rats by administration of streptozotocin (60mg/kg) in ice cold citrate buffer (pH 4.3). Results of pharmacological activities revealed that the ethanol extract of the plant leaves showed the significant (p?0.001) anti-inflammatory and anti-diabetic activities in a dose of 200mg/kg and 400 mg/kg body weight. The ethanol extract of leaves of A.madraspatana possess the anti-inflammatory and anti-diabetic activities.
Cite this article:
J. Padmavathy, T. Venkatachalam, I. Sarath Chandiran, S. G. Raman, R. Rajkumar, D. Saravanan. Evaluation of Anti-inflammatory and Anti-diabetic activities of Actinodaphne madraspatana bedd leaves. Research J. Pharm. and Tech. 2021; 14(1):47-51. doi: 10.5958/0974-360X.2021.00009.3
Cite(Electronic):
J. Padmavathy, T. Venkatachalam, I. Sarath Chandiran, S. G. Raman, R. Rajkumar, D. Saravanan. Evaluation of Anti-inflammatory and Anti-diabetic activities of Actinodaphne madraspatana bedd leaves. Research J. Pharm. and Tech. 2021; 14(1):47-51. doi: 10.5958/0974-360X.2021.00009.3 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-1-9
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