Author(s):
Doppalapudi Sandeep, Suryadevara Vidyadhara, Yallam Sailaja, Battula Sowjanya Lakshmi, Nayudu Vanya
Email(s):
pharmacydeepu@gmail.com
DOI:
10.52711/0974-360X.2021.00895 
Address:
Doppalapudi Sandeep*, Suryadevara Vidyadhara, Yallam Sailaja, Battula Sowjanya Lakshmi, Nayudu Vanya
Department of Pharmaceutics, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chandramoulipuram, Chowdavaram, Guntur, Andhra Pradesh, India – 522019.
*Corresponding Author
Published In:
Volume - 14,
Issue - 10,
Year - 2021
ABSTRACT:
The present work mainly focuses on solubility enhancement of poorly soluble drugs using superdisintegrants. One of such poorly soluble drugs is Atorvastatin, which belongs to the category of statins. Atorvastatin belongs to BCS class – II, which is poorly water soluble and highly permeable. Natural sources are now-a-days playing a key role in pharmaceutical research. They have several pharmaceutical applications. Starches obtained from plants are pharmaceutically useful as binders, diluents, disintegrants and lubricants. Various physical parameters were evaluated. Solid dispersions were prepared using solvent evaporation technique. Where as in solid dispersions, formulations F2 and F5 showed better dissolution rate compared with other formulations. Fourier Transform Infra red spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC) studies for optimized formulations revealed that there were no major interactions between the drug and excipients. X-Ray Diffraction (XRD) studies revealed the crystalline and amorphous nature of formulations. Scanning Electron Microscopy (SEM) revealed the surface characteristics. Thus from the present study, it was concluded that Entada scandens seed starch posses superdisintegrant property.
Cite this article:
Doppalapudi Sandeep, Suryadevara Vidyadhara, Yallam Sailaja, Battula Sowjanya Lakshmi, Nayudu Vanya. Formulation and Evaluation of Atorvastatin Solid Dispersions using Entada scandens seed starch as Superdisintegrant. Research Journal of Pharmacy and Technology. 2021; 14(10):5141-9. doi: 10.52711/0974-360X.2021.00895
Cite(Electronic):
Doppalapudi Sandeep, Suryadevara Vidyadhara, Yallam Sailaja, Battula Sowjanya Lakshmi, Nayudu Vanya. Formulation and Evaluation of Atorvastatin Solid Dispersions using Entada scandens seed starch as Superdisintegrant. Research Journal of Pharmacy and Technology. 2021; 14(10):5141-9. doi: 10.52711/0974-360X.2021.00895 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-10-13
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