Author(s):
Kavitha J, Bonda Vismitha, Kokilambigai KS, Seetharaman R, Lakshmi KS
Email(s):
kavitha0208@gmail.com
DOI:
10.52711/0974-360X.2021.00985 
Address:
Kavitha J*, Bonda Vismitha, Kokilambigai KS, Seetharaman R, Lakshmi KS
Department of Pharmaceutical Analysis, SRM College of Pharmacy, SRM Institute of Science and Technology, SRM Nagar, Kattankulathur - 603203, Chengalpattu district, Tamil Nadu, India.
*Corresponding Author
Published In:
Volume - 14,
Issue - 11,
Year - 2021
ABSTRACT:
Oxetacaine is a potent local anesthetics used to relieve pain associated with peptic ulcer. The current method details about a rapid, accurate and precise HPTLC technique for the assessment of Oxetacaine in Pharmaceutical formulation. Chromatographic resolution was carried out on precoated HPTLC plates (Silica gel 60 F254 on Aluminum plate) employing methanol: water: glacial acetic acid (8: 1.8: 0.2 v/v/v) as mobile phase. Densitometric assessment was carried out at 220nm [Camag TLC Scanner III with winCATs software (version – 1.3.4)]. The drug was identified with a Rf value of 0.61. The reliability of the projected method was ascertained by evaluating various validation parameters as per ICH guidelines. The proposed technique can evaluate ten or more formulation units concurrently in a single run and affords a more rapid and cost-effective QC tool for regular analysis of Oxetacaine in pharmaceutical formulations.
Cite this article:
Kavitha J, Bonda Vismitha, Kokilambigai KS, Seetharaman R, Lakshmi KS. Validated HPTLC Method for the Estimation of Oxetacaine in Pharmaceutical Formulations. Research Journal of Pharmacy and Technology. 2021; 14(11):5668-2. doi: 10.52711/0974-360X.2021.00985
Cite(Electronic):
Kavitha J, Bonda Vismitha, Kokilambigai KS, Seetharaman R, Lakshmi KS. Validated HPTLC Method for the Estimation of Oxetacaine in Pharmaceutical Formulations. Research Journal of Pharmacy and Technology. 2021; 14(11):5668-2. doi: 10.52711/0974-360X.2021.00985 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-11-10
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