Author(s):
Mounica Ponugoti, Siva Prasad Panda, Umasankar Kulandaivelu, GSN Koteswara Rao, Rajasekhar Reddy Alavala, Nallaparaju Jagadeesh Varma
Email(s):
mounicaponuganti@gmail.com
DOI:
10.52711/0974-360X.2021.00998 
Address:
Mounica Ponugoti1,2*, Siva Prasad Panda3, Umasankar Kulandaivelu3, GSN Koteswara Rao3, Rajasekhar Reddy Alavala3, Nallaparaju Jagadeesh Varma4
1Research Scholar, College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur - 522502, Andhra Pradesh, India.
2Assistant Professor, Department of Pharmacology, Hindu College of Pharmacy, Amaravathi Road, Guntur – 522002, Andhra Pradesh, India.
3Associate Professor, College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur - 522502, Andhra Pradesh, India.
4Student M.sc (Organic Chemistry), Department of Organic Chemistry, Foods, Drugs and Water, Andhra University, Visakhapatnam– 530003, Andhra Pradesh, India.
*Corresponding Author
Published In:
Volume - 14,
Issue - 11,
Year - 2021
ABSTRACT:
Senegalia rugata (Lam.) Britton & Rose, Synonym: Acacia concinna (Wild.) DC., Family: Fabaceae is one of the ayurvedic medicinal plant and commonly known as shikakai. The pods of S. rugata are normally used for cleansing of hair naturally due to the presence of higher content of saponins. In this study, we have isolated six compounds consisting of epigallocatechin (monomeric proanthocyanidin) from ethanol extract of S. rugata and a mixture of methyl esters of five polyunsaturated fatty acids (PUFA): methyl oleate, glyceryl trilinoleate, methyl linoleate methyl eicosenoate and methyl vernolate from petroleum ether extract of S rugata. The structures of the six compounds were elucidated using 1HNMR, 13CNMR and IR spectral studies. Epigallocatechin has shown significant in vitro anti-inflammatory property in a dose-dependent manner using the HRBC membrane stabilization method.
Cite this article:
Mounica Ponugoti, Siva Prasad Panda, Umasankar Kulandaivelu, GSN Koteswara Rao, Rajasekhar Reddy Alavala, Nallaparaju Jagadeesh Varma. Isolation and Evaluation of Anti-inflammatory activity of Epigallocatechin from Senegalia rugata along with PUFAs. Research Journal of Pharmacy and Technology. 2021; 14(11):5739-4. doi: 10.52711/0974-360X.2021.00998
Cite(Electronic):
Mounica Ponugoti, Siva Prasad Panda, Umasankar Kulandaivelu, GSN Koteswara Rao, Rajasekhar Reddy Alavala, Nallaparaju Jagadeesh Varma. Isolation and Evaluation of Anti-inflammatory activity of Epigallocatechin from Senegalia rugata along with PUFAs. Research Journal of Pharmacy and Technology. 2021; 14(11):5739-4. doi: 10.52711/0974-360X.2021.00998 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-11-23
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