Vikas Sharma, Chandana Majee, Rahul Kaushik, Shivani Saxena, Salahuddin, Avijit Mazumdar
Vikas Sharma1*, Chandana Majee1, Rahul Kaushik2, Shivani Saxena,1 Salahuddin 1, Avijit Mazumdar1
1Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, Knowledge Park-2, Greater Noida, Uttar Pardesh-201306, India.
2Department of Pharmacognosy, Ram-Eesh Institute of Vocational and Technical Education, Plot No. 03, Knowledge Park-1, Greater Noida, Uttar Pradesh-201306, India.
Volume - 14,
Issue - 11,
Year - 2021
Herbal digestive tablets are meant for treating indigestion problems. The indigestion problem is one of the major problems of all (the) ages of human beings. As trends for eating fast foods is increasing, simultaneously the improper digestion also tends to increase. There are a number of digestive tablets in the market but in attempt to improve their taste the actual motto behind their use is masked. To combat the indigestion problems, in the present study an attempt has been made to formulate, develop and evaluate herbal digestive tablets. The formula of the digestive tablet has been decided after deep review of Ayurvedic formulary of India. The ingredients of this formulation have been procured from authentic sources. The wet granulation method was used to prepare the granules for punching the tablets. After preparation, the herbal digestive tablets were subjected to various pharmaceutical evaluations and quality control evaluations as per the guidelines from World Health Organization (WHO). The formulation was also subjected to antioxidant screening using Phosphomolybdenum method. The digestive tablets are obtained as light brown-colored round tablets with pleasant odour and spicy taste with an average size of 8mm and smooth edges. Maximum extractive value was observed as 34% in methanol with a total ash value of 10.16%. Other parameters reported as bitterness value- 0.69 units, volatile oil content-8%, loss on drying- 12.3%, swelling and foaming index of 0.27 and less than 100 respectively. The tablets showed a total antioxidant potential of 0.51mg/mg as Ascorbic acid equivalent. Tablets also pass various pharmaceutical evaluation parameters like hardness, friability, weight variation, and disintegration test. Herbal digestive tablets have very excellent taste due to less bitter drugs. The tablet formula can be applied to prepare large scale production of digestive tablets.
Cite this article:
Vikas Sharma, Chandana Majee, Rahul Kaushik, Shivani Saxena, Salahuddin, Avijit Mazumdar. Development of Herbal Ayurvedic Formulation as Digestive Tablets, Evaluation of it’s Pharmaceutical, Pharmacognostic Parameters and Screening of its Antioxidant Potential. Research Journal of Pharmacy and Technology. 2021; 14(11):5849-5. doi: 10.52711/0974-360X.2021.01018
Vikas Sharma, Chandana Majee, Rahul Kaushik, Shivani Saxena, Salahuddin, Avijit Mazumdar. Development of Herbal Ayurvedic Formulation as Digestive Tablets, Evaluation of it’s Pharmaceutical, Pharmacognostic Parameters and Screening of its Antioxidant Potential. Research Journal of Pharmacy and Technology. 2021; 14(11):5849-5. doi: 10.52711/0974-360X.2021.01018 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-11-43
1. Zaveri M, Khandhar A, Patel S, Patel A. Chemistry and pharmacology of Piper longum L. International Journal of Pharmaceutical Sciences Review and Research. 2010 Nov;5(1):67-76.
2. World Health Organization. Quality control methods for medicinal plant materials. World Health Organization; 1998.
3. Rohan R. Vakhariya, Swati Talokar, Archana R. Dhole, S.K. Mohite, C.S. Magdum . Comparative Standardization Study of Two Marketed Shatavari Churna Formulation. Asian J. Pharm. Ana. 6(1): January- March, 2016; Page 1-6.
4. Khushtar M. Medicinal and pharmacological role of traditional Asian Food condiment: Cinnamomum zeylanicum Blume.
5. Jesylne P, Soundarajan S, Murthykumar K, Meenakshi M. The role of cardamom oil in oral health: A short review. Research Journal of Pharmacy and Technology. 2016;9(3):272-4.
6. Platel K, Srinivasan K. Influence of dietary spices or their active principles on digestive enzymes of small intestinal mucosa in rats. International Journal of Food Sciences and Nutrition. 1996 Jan 1;47(1):55-9.
7. Trigui I, Zarai Z, Chevance S, Cheikh-Rouhou S, Attia H, Ayadi MA. Physicochemical properties, antioxidant activity and in vitro gastrointestinal digestion of purified proteins from black cumin seeds. International Journal of Biological Macromolecules. 2019 Apr 1; 126:454-65.
8. Meghwal M, Goswami TK. Chemical Composition, Nutritional, Medicinal And Functional Properties of Black Pepper: A Review. 2012, 1(2): 172. doi: 10.4172/scientificreports.
9. Awasthi KK, Pandey A. Utilization of Traditional Herbs, Spices, Seasoning and Condiments: A Case Study of the Preparation of “Buknu” in Selected Villages of Kanpur, Uttar Pradesh, India. European Journal of Medicinal Plants. 2016 Apr 6:1-1.
10. Kaushik R. Trikatu-A combination of three bioavailability enhancers. International Journal of Green Pharmacy (IJGP). 2018 Nov 6;12(03).
11. Terra WR, Valentin A, Santos CD. Utilization of sugars, hemicellulose, starch, protein, fat and minerals by Erinnyis ello larvae and the digestive role of their midgut hydrolases. Insect Biochemistry. 1987 Jan 1;17(8):1143-7.
12. Malarkodi Velraj, Ranjit Singh, B. Rathore, V. Ravichandiran, S. Jayakumari , Sanjay Ragala. Standardization and Preliminary Phytochemical Studies on the Bark of Madhuca indica J.F.G. Mel. Research J. Pharmacognosy and Phytochemistry 2011; 3(5): 221-224.
13. Kaushik R, Sharma B. Establishment of monograph of acorus calamus linn. Rhizomes. Journal of Drug Delivery and Therapeutics. 2012 May 14; 2(3).
14. S. Sakthi Priyadarsini, R Vadivu, N Jayshree. Pharmacognostic evaluation Standardization of Leaves of Ravenala madagascariensis Sonn. Research J. Pharmacognosy and Phytochemistry. 2010; 2(4): 288-292.
15. Jiby Elias, Rajesh M.G., Anish N.P., Ragitha E.V., Jayan N.Pharmacognostic Standardization of Solanum melongena var. insanum Linn. Research J. Pharmacognosy and Phytochemistry. 2010; 2(5): 364-367.
16. Swati Talokar, Rohan R Vakhariya, A.R Dhole. Comparative Standardization of Two Marketed Preparation of Gulwel churna. Res. J. Pharm. Dosage Form. & Tech. 9(1): Jan.-Mar. 2017; Page 24-28.
17. P. Bigoniya, C. S. Singh, B. Shrivastava. Pharmacognostic evaluation, physico-chemical and phyto-chemical standardization of Cichorium intybus L. seed. Research J. Pharmacognosy and Phytochemistry. 2013; 5(3): 133-138.
18. Hayat M. Mukhtar, Manwinder Singh, Deepika Vashishth, Sandeep Singh, Harjas Kaur. Standardization of the dried aerial parts of Bidens pilosa. Research J. Pharmacognosy and Phytochemistry. 2013; 5(2): 84-86.
19. Hayat M. Mukhtar, Harjas Kaur, Sandeep Singh, Manwinder Singh. Standardization and Preliminary Phytochemical Investigation of the Fruits of Grewia asiatica Linn. Research J. Pharmacognosy and Phytochemistry. 2012; 4(4): 212-214.
20. Sharma V, Kaushik R, Rai P. Comparative Study of Herbal Formulation and Marketed Formulation of Triphala Churna. International Journal of Pharmaceutical Education and Research (IJPER). 2020 Jun 10;2(01):21-9.
21. Ajay Kumar Meena, Brijendra Singh, Vijay Simha, V. Gautam, M. M. Rao. A Comparative study for quality assessment of various location samples of Withania somnifera Dunal. Research J. Pharmacognosy and Phytochemistry. 2012; 4(1): 14-17.
22. Kaushik R, Jain J, Rai P, Sharma Y, Kumar V, Gupta A. Pharmacognostic evaluation, Physicochemical and Preliminary Phytochemical studies of Anthocephalus cadamba (Roxb.) Leaves. Research Journal of Pharmacy and Technology. 2018; 11(4): 1391-7.
23. Jadhav Santosh, Sawale Jyotiram. Standardization of Poly-herbal Formulations: A Comprehensive Review. Res. J. Pharmacognosy and Phytochem. 2016; 8(2): 85-89.