Author(s):
K Poojita, Fajeelath Fathima, Rajdeep Ray, Lalit Kumar, Ruchi Verma
Email(s):
ruchi.verma@manipal.edu , ruchiverma_farma@yahoo.com
DOI:
10.52711/0974-360X.2021.01026 
Address:
K Poojita1, Fajeelath Fathima1, Rajdeep Ray1, Lalit Kumar2, Ruchi Verma1*
1Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal academy of Higher Education, Madhav Nagar-576104, Manipal, Udupi, Karanataka, India.
2Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal academy of Higher Education, Madhav Nagar-576104, Manipal, Udupi, Karanataka, India.
*Corresponding Author
Published In:
Volume - 14,
Issue - 11,
Year - 2021
ABSTRACT:
Tuberculosis disease is world’s biggest threat to health with a high mortality rate. There has been a steady surge in the frequency of MDR-TB and XDR-TB. Hence, it is imperative to encourage the research and development of novel drugs to counteract the infection. Decaprenylphosphoryl-ß-D-ribose-2'a-epimerase 1 (DprE1) is a valuable enzyme which is responsible for the stability and virulence of the infection causing bacteria (Mycobacterium tuberculosis) thereby making it a perfect target for drugs anti TB activity. This study represent atom based 3D QSAR model consisting the derivatives of DprE1 inhibitors and provides guidance and insight to develop and identify new novel molecule which have good therapeutic efficiency as Anti TB drugs.
Cite this article:
K Poojita, Fajeelath Fathima, Rajdeep Ray, Lalit Kumar, Ruchi Verma. 3D Atom based QSAR model of DprE1 inhibitors as Anti-tubercular Agents. Research Journal of Pharmacy and Technology. 2021; 14(11):5903-0. doi: 10.52711/0974-360X.2021.01026
Cite(Electronic):
K Poojita, Fajeelath Fathima, Rajdeep Ray, Lalit Kumar, Ruchi Verma. 3D Atom based QSAR model of DprE1 inhibitors as Anti-tubercular Agents. Research Journal of Pharmacy and Technology. 2021; 14(11):5903-0. doi: 10.52711/0974-360X.2021.01026 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-11-52
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