Author(s): Pushpa Latha E., Sailaja B.

Email(s): latha.pushpa999@gmail.com

DOI: 10.52711/0974-360X.2021.01043   

Address: Pushpa Latha E.*, Sailaja B.
Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam, Tirupati, AP, India- 517502.
*Corresponding Author

Published In:   Volume - 14,      Issue - 11,     Year - 2021


ABSTRACT:
Analytical UV derivative spectrophotometric method was developed and validated to quantify Rizatriptan Benzoate in pure drug and tablet dosage form. Based on the spectrophotometric characteristics of Rizatriptan Benzoate, a signal of zero (225nm), first (216nm), second (237nm), third (233nm), fourth (231nm) order derivative spectra were found to be adequate for quantification. The methods obeyed Beer's law in the concentration range of (0.1-360µg/ml) with square correlation coefficient (r2) of 0.999. The mean percentage recovery was found to be 100.01 ± 0.075. As per ICH guidelines the results of the analysis were validated in terms of linearity, precision, accuracy, limit of detection and limit of quantification, and were found to be satisfactory.


Cite this article:
Pushpa Latha E., Sailaja B. Method Development and Validation of Spectrophotometric Methods for The Estimation of Rizatriptan Benzoate in Pure and Pharmaceutical Dosage Form. Research Journal of Pharmacy and Technology. 2021; 14(11):6003-6. doi: 10.52711/0974-360X.2021.01043

Cite(Electronic):
Pushpa Latha E., Sailaja B. Method Development and Validation of Spectrophotometric Methods for The Estimation of Rizatriptan Benzoate in Pure and Pharmaceutical Dosage Form. Research Journal of Pharmacy and Technology. 2021; 14(11):6003-6. doi: 10.52711/0974-360X.2021.01043   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-11-69


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