Anjali Sharma, Kumar Guarve, Ranjit Singh
Anjali Sharma1,2, Kumar Guarve1, Ranjit Singh2*
1Guru Gobind Singh College of Pharmacy, Yamunanagar-135001, Haryana.
2Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University, Gangoh, Saharanpur-247001, Uttar Pradesh.
Volume - 14,
Issue - 12,
Year - 2021
Background: The aim of the present investigation was to develop optimized Aceclofenac-loaded microsponges using Box-Behnken design (BBD) and desirability function. Material and Method: Aceclofenac-loaded microsponges were developed using ethyl cellulose, ethanol and polyvinyl alcohol (PVA). Initially, a trial batch was developed using quasi-emulsion solvent diffusion method, and by optimizing the drug-polymer ratio. A 3-level, 3-factor BBD was used to investigate the effect of PVA, ethanol and stirring speed on particle size and entrapment efficiency (EE). The models used for the optimization were analyzed through ANOVA and diagnostic plots. Finally, the desirability function was used for the selection of optimized formulation composition. Results: A drug-polymer ratio of 1.5:1 was taken as optimized ratio for all the formulations. The developed microsponges were of the spherical shape having size and %EE in the range of 22.54±2.85 µm to 49.08±5.01 µm and 70.57±4.19% to 86.43±2.58 %, respectively. The amounts of PVA, ethanol and stirring speed were noted to have a significant impact on particle size and %EE. Finally, an optimized formulation (size-22.69 and %EE-86.42) was developed with a desirability value of 0.9967. Conclusion: The BBD is a valuable tool for the development of optimized microsponges with desired properties.
Cite this article:
Anjali Sharma, Kumar Guarve, Ranjit Singh. Application of Box–Behnken Design and Desirability function in the Optimization of Aceclofenac-Loaded Micropsonges for Topical Application. Research Journal of Pharmacy and Technology. 2021; 14(12):6295-3. doi: 10.52711/0974-360X.2021.01089
Anjali Sharma, Kumar Guarve, Ranjit Singh. Application of Box–Behnken Design and Desirability function in the Optimization of Aceclofenac-Loaded Micropsonges for Topical Application. Research Journal of Pharmacy and Technology. 2021; 14(12):6295-3. doi: 10.52711/0974-360X.2021.01089 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-12-19
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