Abhinav Mishra, Vikram Singh, Raj K Prasad, Mohd Habeeb Ahmad
Abhinav Mishra*, Vikram Singh, Raj K Prasad, Mohd Habeeb Ahmad
Shambhunath Insitute of Pharmacy, Jhalwa, Prayagraj, Uttar Pradesh, India.
Volume - 14,
Issue - 12,
Year - 2021
In the present investigation the glucose lowering potential of the leaf extracts of Crinum asiaticum were prepared using cold maceration technique in solvents of varying polarity. The extracts exhibited the presence of flavonoids, alkaloids, phenolics and tannins. The oral toxicity of the aqueous and ethanolic extracts was determined and these two extracts were used of evaluating the antidiabetic activity. Oral glucose tolerance test was performed and diabetes was induced using alloxan (150 mg/kg) in rats. Ethanolic and aqueous extracts at two dose levels (200 mg/kg and 400mg/kg) were used for evaluating glucose lowering capability. Both the aqueous and the ethanolic extracts were found to significantly reduce glucose levels with the aqueous extract at dose level 200 mg/kg being the most effective (50% reduction) whereas the ethanolic extract was able to reduce the blood glucose by around 35% at the same dose level.
Cite this article:
Abhinav Mishra, Vikram Singh, Raj K Prasad, Mohd Habeeb Ahmad. Ameliorative potential of Crinum asiaticum Linn leaf extracts on Elevated blood glucose in Alloxan-induced Diabetic Rats. Research Journal of Pharmacy and Technology. 2021; 14(12):6359-3. doi: 10.52711/0974-360X.2021.01099
Abhinav Mishra, Vikram Singh, Raj K Prasad, Mohd Habeeb Ahmad. Ameliorative potential of Crinum asiaticum Linn leaf extracts on Elevated blood glucose in Alloxan-induced Diabetic Rats. Research Journal of Pharmacy and Technology. 2021; 14(12):6359-3. doi: 10.52711/0974-360X.2021.01099 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-12-29
1. Kazeem MI, Abimbola SG and Ashafa AOT. Inhibitory potential of Gossypium arboreum leaf extracts on diabetes key enzymes, α-amylase and α-glucosidase. Bangladesh Journal of Pharmacology. 2013; 8(2): 149-155.
2. Bhandole AB and Suryawanshi V. Neuropharmacological activity of Azadirachta indica Leaves on Diabetes Rodunts. Journal of Pharmacology and Biomedicine. 2017; 1(4): 134-138.
3. Kiritikar KR and Basu, BD. Indian Medicinal Plants. International Book Distributor, Dehradun. 1999.
4. Macharla SP, Goli and Ravinder Nath A. Antidiabetic Activity of Bambusa arundinaceae Root Extracts on Alloxan Induced Diabetic Rats. Asian Journal of Research in Pharmaceutical Sciences. 2012; 2(2): 73-75.
5. Sawant SS, Randive VR and Kulkarni SR. Lectins from seeds of Abrus precatorius: Evaluation of Antidiabetic and Antihyperlipidemic Potential in Diabetic Rats. Asian Journal of Pharmaceutical Research. 2017; 7(2): 71-80.
6. Thennarasan S, Murugesan S and Sivamurugan V. Antidiabetic efficacy of Methanol extract Brown Alga Lobophora variegata on Alloxan stimulated Hyperglycemic Wistar Albino Rats. Asian Journal of Pharmaceutical Techology. 2017; 7 (3): 157-165
7. Sudha T, Akila Devi D and Kaviarasan L. Antihyperlipidemic effect of Stevia rebaudiana on Alloxan Induced Diabetic Rats. Asian Journal of Pharmaceutical Techology. 2017; 7 (4):202-208.
8. Sugumaran M, Vetrichelvan T and Darlin Quine S. Antidiabetic potential of aqueous and alcoholic leaf extracts of Pithecellobium dulce. Asian Journal of Research in Chemistry. 2009; 2(1): 83-85.
9. Radhika K, Kumaravel B, Thamizhiniyan V and Subramanian S. Biochemical evaluation of antidiabetic activity of Piper betel leaves extract in alloxan-induced diabetic rats. Asian Journal of Research in Chemistry. 2013; 6(1): 76-82.
10. Dongare SS, Maske AP, Patil SM, Umbare RP and Mate GS. Antidiabetic Activity of Marsilea quadrifolia linn in Alloxan-Diabetic Rats. Research Journal of Pharmacognosy and Phytochemistry 2009; 1(1):15-17.
11. Amutha K and Aishwarya S. Evaluation of Antibacterial and Antidiabetic Activity and Phytochemical Analysis of Syzygium cumini (l.) Skeels. Seed. Research Journal of Pharmacology and Pharmacodynamics. 2010; 2(5): 348-350.
12. Vadivelan R, Dhanabal SP, Patil Mohan, Shanish A, Elango K and Suresh B. Antidiabetic Activity of Mukia maderaspatana (L) Roem in Alloxan Induced Diabetic Rats. Research Journal of Pharmacology and Pharmacodynamics. 2010; 2(1):78-80 .
13. Panchal M, Shah B, Murti K and Shah M. Phytochemical investigation and antidiabetic activity studies of Moringa oliefera roots. Research Journal of Pharmacology and Pharmacodynamics. 2011; 3(5): 268-277.
14. Indradevi S, Ilavenil S, Kaleeswaran B, Srigopalram S and Ravikumar S. Ethanolic extract of Crinum asiaticum attenuates hyperglycemia-mediated oxidative stress and protects hepatocytes in alloxan induced experimental diabetic rats. Journal of King Saudi University-Science. 2012; 24: 171-177.
15. Sahira Banu K and Cathrine L. General Techniques Involved in Phytochemical Analysis. International Journal of Advances in Research in Chemical Sciences. 2015; 2(4): 25-32
16. Okokon JE, Bassey AL and Obot J. African Journal of traditional, complementary and alternative medicine. 2006; 37(4), 21-26.
17. Vadivelan R, Umasankar P, Dipanjan M, Dhanabal SP, Shanish A, Satishkumar MN, Elanko K. Der Pharmacia Sinica. 2011; 2(2), 299-304
18. Chandana M. Puttaraju and Manorama Eti. WHO 75 gram OGTT-A single step procedure for screening and diagnosis of gestational diabetes mellitus. International Journal of Reproduction Contraception Obstetrics and Gynecology. 2015; 4(6): 2022-2027.
19. Shetti AA, Sanakal RD and Kaliwal BB. Antidiabetic effect of ethanolic leaf extract of Phyllanthus amarus in alloxan induced diabetic mice. Asian Journal of Plant Science Research. 2012, 2(1): 11-15
20. Szkudelski T. The mechanism of alloxan and streptozotocin action in B-cells of the rat pancreas. Physiology Research. 2001; 50: 536.