Author(s): Pravin S. Tajane, Ramesh L. Sawant, Ganesh K. Dhikale, Ganesh D. Barkade

Email(s): pravintajane2509@gmail.com

DOI: 10.52711/0974-360X.2021.01101   

Address: Pravin S. Tajane1*, Ramesh L. Sawant2, Ganesh K. Dhikale1 , Ganesh D. Barkade1
1Ph. D. Research Scholar, Department of Pharmaceutical Chemistry, Dr. Vithalrao Vikhe Patil Foundation’s College of Pharmacy, Ahmednagar (M. S.) India.
2Professor, Department of Pharmaceutical Chemistry, Dr. Vithalrao Vikhe Patil Foundation’s College of Pharmacy, Ahmednagar (M. S.) India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 12,     Year - 2021


ABSTRACT:
Benzimidazole derivatives of substituted 2 [2-(3-nitrophenyl)-1H-benzimidazole-1-yl] acetamide analogues were synthesized and studied for antihelminthic activity. Compounds 3a–o were obtained in three steps, starting with the Oxidative Condensation of the appropriate 3-nitrobenzaldeyde, o-phenylenediamine and sodium hydrogen sulfite to form 2-(3-nitrophenyl)-1H-benzimidazole (1a). In second step Nucleophilic substitution, Chlorine atom of ethylchloroacetate will attach on nitrogen of benzimidazole by replacing hydrogen with elimination of hydrochloric acid to form ethyl [2-(3-nitrophenyl)-1H-benzimidazole-1-Yl acetate (2a).In third step amide formation from ester takes place by substitution of electrophilic with loss of ethanol to form substituted 2 [2-(3-nitrophenyl)-1H-benzimidazole-1-yl] acetamide 3a–o The antihelminthic activity showed that compounds 3f, 3h, 3i, 3j and 3k good activity against Indian earthworms (Pheretima posthuma) in comparison to albendazole.


Cite this article:
Pravin S. Tajane, Ramesh L. Sawant, Ganesh K. Dhikale, Ganesh D. Barkade. Synthesis and Molecular Modeling Studies of 2-[2-(3-nitrophenyl)-1h-benzimidazol-1-yl]-acetamide Derivatives as Anthelmintic. Research Journal of Pharmacy and Technology. 2021; 14(12):6369-3. doi: 10.52711/0974-360X.2021.01101

Cite(Electronic):
Pravin S. Tajane, Ramesh L. Sawant, Ganesh K. Dhikale, Ganesh D. Barkade. Synthesis and Molecular Modeling Studies of 2-[2-(3-nitrophenyl)-1h-benzimidazol-1-yl]-acetamide Derivatives as Anthelmintic. Research Journal of Pharmacy and Technology. 2021; 14(12):6369-3. doi: 10.52711/0974-360X.2021.01101   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-12-31


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