Author(s): Prakash Nargatti, Sudhir Patil, Sandip Patil, Nilofar Naikwade


DOI: 10.5958/0974-360X.2021.00137.2   

Address: Prakash Nargatti1*, Sudhir Patil2, Sandip Patil3,4, Nilofar Naikwade2
1Department of Pharmacology, Annasaheb Dange College of Pharmacy, Ashta, Sangli, Maharashtra, India.
2Department of Pharmacology, Appasaheb Birnale College of Pharmacy, Sangli, Maharashtra, India.
3Department of Pharmacology, Dr. Shivajirao Kadam College of Pharmacy, Kasbe Digraj, Sangli, Maharashtra, India
4Biocyte Institute of Research & Development, Sangli, Maharashtra, India
*Corresponding Author

Published In:   Volume - 14,      Issue - 2,     Year - 2021

Psychosocial stress increasingly recognized as an important health issue in development and progression of cancer. Prostate cancer patients have increased levels of stress and anxiety. Several studies suggest that environmental factors are important in prostate cancer development. Patients with prostate cancer reportedly show higher levels of anxiety compared with other cancer patients. Based on psychoneuroimmunology we report that stress promotes prostate cancer in rats through stress response system. The sympathetic nervous system potentially regulate tumour a and ß-adrenergic signalling both via circulating adrenaline/nor-adrenaline and via local nor-adrenaline release from SNS nerve fibres. Activation of the sympathetic nervous system promotes cancer progression via ß-adrenoreceptor–mediated activation of protein kinase A and exchange protein activated by adenylyl cyclase signalling pathways. Stimulation of a¬ receptor leads to the activation of Ca++ permeable no selective cationic channels and transient receptor potential (TRP) channel family, which are responsible for cell proliferation, which leads to prostate cancer progression. Certain adrenergic blockers can exert anticancer activity by blocking a and ß adrenergic pathway. Thus current study examined association between prostate cancer progression and behavioural study. Our findings could be used to new clinical and treatment strategies in cancer therapy.

Cite this article:
Prakash Nargatti, Sudhir Patil, Sandip Patil, Nilofar Naikwade. Chemopreventive potential of adrenergic blocker in behavioral stress accelerated prostate cancer development in rats. Research J. Pharm. and Tech. 2021; 14(2):787-792. doi: 10.5958/0974-360X.2021.00137.2

Prakash Nargatti, Sudhir Patil, Sandip Patil, Nilofar Naikwade. Chemopreventive potential of adrenergic blocker in behavioral stress accelerated prostate cancer development in rats. Research J. Pharm. and Tech. 2021; 14(2):787-792. doi: 10.5958/0974-360X.2021.00137.2   Available on:

1.    Smith M., Susan K Lutgendorf and Anil K Sood, ‘Impact of stress on cancer metastasis’, Future Oncology, 2010; 6(12): 1863-1881
2.    Hassan S., Karpova Y., Baiz D., Yancey D., Pullikuth A., Flores A., Register T., Cline J., D’Agostino R., Daniel N., Datta S. and Kulik G., ‘Behavioral stress accelerates prostate cancer development in mice’, The Journal of Clinical Investigation, 2013; 123(2): 874-886.
3.    Reiche E., Nunes S. and Morimoto H., ‘Stress, depression, the immune system and cancer’, The Lancet oncology, 2004; 5: 617-625.
4.    Ader R., Cohen N., Felten D., ‘Psychoneuroimmunology: interactions between the nervous systems and the immune system’, Lancet, 1995; 345: 99-103
5.    Hughes C., Murphy A., Martin C., Sheils O., O’Leary J, ‘Molecular pathology of prostate cancer’, Journal of Clinical Pathology, 2005; 58: 673–684.
6.    Cole S.W. and Sood A.K., ‘Molecular Pathways: Beta-Adrenergic Signaling in Cancer’, Clinical Cancer Research, 2012; 18(3): 1201-1206.
7.    The bault S., Roudbaraki M., Sydorenko V., Shuba Y., Lemonnier L., Slomianny C., Dewailly E., Bonnal J.L., Mauroy B., Skryma R. and Prevarskaya N., ‘α1-adrenergic receptors activate Ca++-permeable cationic channels in prostate cancer epithelial cells’, The Journal of Clinical Investigation, 2003; 111(11): 1691-1701.
8.    Lindgren M.E., Fagundes C.P. Alfano C.M., Povoski S.P., Agnese D.M., Arnold M.W., Farrar W.B, Yee L.D., Carson W.E., Schmidt C.R. and Kiecolt-Glaser J.K., ‘Beta-blockers may reduce intrusive thoughts in newly diagnosed cancer patients’, Psycho-Oncology, 2012.
9.    M. Vaishali, ‘Antioxidants in Health and Diseases’, Research Journal of Pharmacy and Technology,2014;7(14): 489-493.
10.    Klenerova V, Jurcovicova J, Kaminsky O, ‘Combined restraint and cold stress in rats: effects on memory processing in passive avoidance task and on plasma levels of ACTH and corticosterone’, Behav Brain Res, 2003; 142: 143-149.
11.    Nagaraja H.S and Jeganathan P.S., ‘Influence of different types of stress on selected cardiovascular parameters in rats’, Indian J Physiol Pharmacol, 1999; 43(3): 296-304.
12.    Nayanatara A.K, Nagaraja H.S., and Anupama B.K., ‘The effect of repeated swimming stress on organ weights and lipid peroxidation in rats’, Thai journal of physiological sciences, 2005; 18(1): 3-9.
13.    Kaniz Fatima Urmi, Ashraf Uddin Chowdhury, Farhana Diba, Khandaker Ashfaqur Rahman, Razibul Habib, Kaiser Hamid, ‘Evaluation of Antioxidant and Cytotoxic Potential of Different Extracts from the Leaves of Aegle marmelos L’, Research Journal of Pharmacy and Technology, 2003; 6(4): 384-387.
14.    V.A. Kangralkar, A.R. Kulkarni, In Vitro Cytotoxic Activity of Alcoholic Extract of Aristolochiaindica, Research Journal of Pharmacy and Technology, 2013; 6(11): 1240-1241
15.    Egbuonu A.C.C., Ejikeme P.M. and Obidoa O., ‘Combined oral arginine and monosodium glutamate exposure induces adverse response on prostate function and testis histology of rats’, British Journal of Pharmaceutical Research, 2013; 3(2): 247-258.
16.    Venkata Naveen Kasagana, Swathi Sree Karumuri, Effect of Wedelia paludosa (Asteraceae) on Brain Neurotransmitters and Enzyme Monoamine Oxidase, Following Cold Immobilization Stress, Research Journal of Pharmacy and Technology, 2011; 4 (12): 1910-1911
17.    Bhatia N., Maiti P.P., Choudhary A., Tuli A, Masih D., Masih M., ‘Animal models in the study of stress: A review, Journal of Pharmacy and Healthcare Management, 2011; 2: 42-50.
18.    Shameer Pasha, Nitin Mahurkar and Jayaveera K.N, ‘Evaluation of Antistress Activity of Vitis vinifera and Chicoriumintybus’, Research Journal of Pharmacy and Technology,2014;7(12):1377-1381.
19.    John. D. Milton, M. Alvin Jose, ‘Anticancer Activity of Ethyl Acetate Root Extract of Xanthium strumarium Linn. in N-Nitroso N-Methyl Urea Induced Mammary Carcinoma in Female Sprague-Dawley Rats’, Research Journal of Pharmacy and Technology,2016;9(8):1115-1118.
20.    Pragati Khare, Kamal Kishore, Dinesh Kumar Sharma, ‘Catalase and Superoxide Dismutase (SOD) activity in Swiss albino mice treated with ethanolic leaf extract of Madhucalongifolia’, Research Journal of Pharmacy and Technology, 2019;12(9):4434-443.
21.    Aebi H. and Bergmeyer H., Catalase methods in enzymatic analysis, Academic press, 1983: 273-276.
22.    Ellman G.L., ‘Tissue sulphydryl group’, Journal of Biochemistry and Biophisiology, 1959; 82: 70-77.
23.    Ohkawa H., Ohishi N. and Yaki K., ‘Assay for lipid peroxides in animal tissues thiobarbituric acid reaction, Anal. Biochem, 1979; 95: 351-358.
24.    Kanagavalli M. and Anuradha R, ‘A Study on Phytochemical Constituents and In Vitro Antioxidant Activity of Carica papaya’, Research Journal of Pharmacy and Technology, 2012;5(1):119-120.
25.    J.S. Vaghela, S.S. Sisodia, ‘In Vitro Antioxidant Activity of Terminalia chebula Fruit Extracts’, Research Journal of Pharmacy and Technology, 2011; 4(12):1835-1843.
26.    Muthana S. Mashkour, Mohammed K. Kahlol, Sami W. AL-Hasnawi, ‘Colorimetric Determination of Metoclopramide Hydrochloride and Glutathione by using 1,2 Naphthaquinolinc-4-Sulphonate Sodium Reagents’, Research Journal of Pharmacy and Technology,2018;11(8): 3290-3294.
27.    Godkar P. and Godkar D., ‘Textbook of Medical Laboratory Technology’, 2nd edition, Bhalani publishing house, Mumbai, 2003.

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