Author(s):
Smita Kumbhar, Vinod Matole, Yogesh Thorat, Saili Madur, Smeeta Patil, Anita Shegaonkar
Email(s):
matole7414@gmail.com
DOI:
10.5958/0974-360X.2021.00161.X 
Address:
Smita Kumbhar, Vinod Matole*, Dr. Yogesh Thorat, Saili Madur, Smeeta Patil, Anita Shegaonkar
D.S.T.S. Mandal’s College of Pharmacy, Solapur-413004.Maharashtra, India.
*Corresponding Author
Published In:
Volume - 14,
Issue - 2,
Year - 2021
ABSTRACT:
Objective: The present research has been undertaken for the formulation and evaluation of lignocaine hydrochloride gel. It is used for topical use for the local anaesthetic activity. Methods: Carbopol 934 was used as a polymer in various batches. The ratio of Carbopol 934 was changed for various batches. Developed Formulations of Physicochemical parameters such as percentage yield, drug content, pH, Viscosity, Spreadability, Extrudability and In-vitro Diffusion study were carried out for developed batches of Lignocaine Hydrochloride. Results: Viscosity studies of various formulations Exhibited that Formulation F2 was better than that of F1 and F3. From among all the developed formulation, F2 Shows better rheological properties and excellent Extrudability. pH of the F2 Batch is Sufficient to treat the pain. Percentage yield and drug content of F2 batch is good than other batches. Results shows that the concentration of Carbopol 934 gives the good rheological properties and drug contents. In-vitro Diffusion studies were carried out, F2 batch shows better results than that of the other two batches i.e. 96.06%. Conclusion: It was concluded that F2 batch is the good than the other batches. So F2 batch is good for the topical use.
Cite this article:
Smita Kumbhar, Vinod Matole, Yogesh Thorat, Saili Madur, Smeeta Patil, Anita Shegaonkar. Formulation and Evaluation of Lignocaine Hydrochloride Topical gel. Research J. Pharm. and Tech. 2021; 14(2):908-910. doi: 10.5958/0974-360X.2021.00161.X
Cite(Electronic):
Smita Kumbhar, Vinod Matole, Yogesh Thorat, Saili Madur, Smeeta Patil, Anita Shegaonkar. Formulation and Evaluation of Lignocaine Hydrochloride Topical gel. Research J. Pharm. and Tech. 2021; 14(2):908-910. doi: 10.5958/0974-360X.2021.00161.X Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-2-57
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