Sugunakar, K. N. Maruthy, Jaffer, Srinivas, Priscilla Johnson
M.B.S. Sugunakar1, Dr. K. N. Maruthy2, Dr. Jaffer3, Dr. Srinivas4, Dr. Priscilla Johnson5*
1M.Sc (Ph.D. Scholar), G.S.L. Medical College, Rajahmundry, A.P.
2Prof., Narayana Medical College.
3M.D, Associate Professor G. S. L. Medical College RJY.
4 Prof and HOD, GSLMC.
5M.D, DNB, Ph.D. Professor, Department of Physiology, Sri Ramachandra Medical College and RI, Porur, Chennai.
Volume - 14,
Issue - 2,
Year - 2021
The following study is conducted between three groups of subjects each group contains n=40 subjects. First the subjects were recruited to department of physiology for conducting study. Screening questionnaire was presented to the study subjects based on their responses according to the inclusion and exclusion criteria subjects were screened. The subjects who met the criteria’s for the study were recruited for the study and informed consent was obtained from the subjects after explaining the process of the study. The study questionnaire was given to the subject to collect the demographic, anthropometric data and socioeconomic status was evaluated by kuppuswami scale (1). The subjects were taken to the autonomic function testing lab in the department of physiology resting blood pressure was measured subject was connected to ECG apparatus to perform heart rate variability (HRV) analysis. The ECG data was acquired using audacity open source software. The data was analyzed using low pass filter at 40Hz and Accelerated pulse wave plethysmography was also obtained using APPG module with soundcard oscilloscope subsequent low pass filter 50Hz was applied and signal was analyzed angle was measured using image J software (2). Introduction: Accelerated photoplethysmography is a measurement tool which is used to evaluate "vascular retro gradation grade" and to detect "arteriosclerosis" by differentiating "volume capacity photoplethysmography" twice on fingertip (3) Aim: To evaluate the relationship between diastolic blood pressure and "arterial compliance" and "peripheral circulation status “using accelerated pulse wave plethysmography (APPG). Methodology: This study was conducted in healthy volunteers (n=40) and in hypertensive’s (n=120). Informed consent was obtained from the study participants and their blood pressure was recorded. Accelerated pulse wave plethysmography was obtained using APPG module with soundcard oscilloscope. Subsequent low pass filter 50Hz was applied and the signal was analyzed. The size of P1, P2, P3, the gradient of P1-P3 and the angle were measured and analyzed using image J software. Results: Rise in diastolic blood pressure leads to a shift in the angle between the P1 and P3 wave. Positive correlation was found between the diastolic blood pressure and the P1 P3 angular shift. (R= 0.2) and it was statistically significant (p <0 .05). Conclusion: This study indicates that rise in diastolic component of blood pressure is associated with more pronounced vascular changes which are detected as a shift in the angle of the APPG component. This non-invasive and cost-effective technique may pave way for early detection of vascular/cardiovascular disorders thereby preventing morbidity and mortality.
Cite this article:
Sugunakar, K. N. Maruthy, Jaffer, Srinivas, Priscilla Johnson. Accelerated Pulse Wave Photo Plethysmography – A Marker of Vascular Compliance and cardiac autonomic functions. Research J. Pharm. and Tech. 2021; 14(2):921-924. doi: 10.5958/0974-360X.2021.00164.5
Sugunakar, K. N. Maruthy, Jaffer, Srinivas, Priscilla Johnson. Accelerated Pulse Wave Photo Plethysmography – A Marker of Vascular Compliance and cardiac autonomic functions. Research J. Pharm. and Tech. 2021; 14(2):921-924. doi: 10.5958/0974-360X.2021.00164.5 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-2-60
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