Author(s): Amir Alhaj Sakur, Dania Nashed, Imad Noureldin

Email(s): profsakur@gmail.com , dania.nashed92@gmail.com

DOI: 10.5958/0974-360X.2021.00226.2   

Address: Amir Alhaj Sakur*, Dania Nashed, Imad Noureldin
Analytical and Food Chemistry Dept., Faculty of Pharmacy, Aleppo University, Syria.
*Corresponding Author

Published In:   Volume - 14,      Issue - 3,     Year - 2021


ABSTRACT:
A new pencil graphite coated electrode was constructed to a potentiometric determination of montelukast sodium (MON). The coating material was a polymeric film consists of polyvinyl chloride (PVC), di-butyl phthalate (DBP), ion pair of drug and strontium nitrate reagent (SR). The sensor exhibited a Nernstian response with a mean calibration graph slope of (28.65 ± 0.07) mV/decade. The linearity range was (10-2-10-5) M, with detection limit 0.19µM and quantification limit 0.57µM. The proposed electrode works effectively in pH range (5-9.5) and the influence of proposed interfering species was negligible. The effectiveness of the graphite sensor continued in a period of time about (35) days. The validation of the newly constructed technique was assumed according to ICH recommendations. The results were studied in comparison with a reference method and the statistical analysis demonstrated that there was no difference in the proposed and previous published methods.


Cite this article:
Amir Alhaj Sakur, Dania Nashed, Imad Noureldin. Novel Pencil Graphite electrode for the Determination of Montelukast sodium in its pure and Pharmaceutical Dosage Forms. Research J. Pharm. and Tech 2021; 14(3):1279-1283. doi: 10.5958/0974-360X.2021.00226.2

Cite(Electronic):
Amir Alhaj Sakur, Dania Nashed, Imad Noureldin. Novel Pencil Graphite electrode for the Determination of Montelukast sodium in its pure and Pharmaceutical Dosage Forms. Research J. Pharm. and Tech 2021; 14(3):1279-1283. doi: 10.5958/0974-360X.2021.00226.2   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-3-14


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