Evaluation of Pharmacological properties, Phytochemistry and Medicinal uses of Linzia glabra (Asteraceae)

Alfred Maroyi

doi:10.5958/0974-360X.2021.00310.3

Research Journal of Pharmacy and Technology

ISSN

0974-360X (Online)
0974-3618 (Print)

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Evaluation of Pharmacological properties, Phytochemistry and Medicinal uses of Linzia glabra (Asteraceae)

Author(s): Alfred Maroyi

Email(s): amaroyi@ufh.ac.za

DOI: 10.5958/0974-360X.2021.00310.3

Address: Alfred Maroyi
Department of Botany, University of Fort Hare, Private Bag X1314, Alice 5770, South Africa.
*Corresponding Author

Published In: Volume - 14, Issue - 3, Year - 2021

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ABSTRACT:
The leaves and roots of Linzia glabra are used as traditional medicines in central and southern Africa. This study is aimed at evaluating the pharmacological properties, phytochemstry and medicinal uses of L. glabra. Results of the current study are based on data derived from several online databases such as Scopus, Google Scholar, PubMed and Science Direct, and pre-electronic sources such as scientific publications, books, dissertations, book chapters and journal articles. This study revealed that the aerial parts, leaves, roots and whole plant parts of L. glabra are widely used as abortifacient, and traditional medicine for respiratory infections, sores, wounds, diabetes, abdominal pains, burns, gonorrhea, syphilis and gastro-intestinal problems. Phytochemical compounds identified from the species include sesquiterpene lactones, alkaloids, flavonoids, glycosides, polyphenols, phytosterols, quinones, sapogenins, saponins, steroids, tannins and terpenoids. Ethnopharmacological research revealed that L. glabra extracts and phytochemical compounds isolated from the species have antibacterial, antifungal, anti-giardial, anti-HIV and antihypertensive activities. Future research on L. glabra should focus on the possible biochemical mechanisms of both the crude extracts and identified phytochemical compounds including toxicological, in vivo and clinical studies to corroborate the traditional medicinal applications of the species.

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Cite this article:
Alfred Maroyi. Evaluation of Pharmacological properties, Phytochemistry and Medicinal uses of Linzia glabra (Asteraceae). Research J. Pharm. and Tech 2021; 14(3):1741-1746. doi: 10.5958/0974-360X.2021.00310.3

Cite(Electronic):
Alfred Maroyi. Evaluation of Pharmacological properties, Phytochemistry and Medicinal uses of Linzia glabra (Asteraceae). Research J. Pharm. and Tech 2021; 14(3):1741-1746. doi: 10.5958/0974-360X.2021.00310.3 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-3-99

REFERENCES:
1.   Robinson H, Skvarla JJ, Funk VA. Vernonieae (Asteraceae) of southern Africa: A generic disposition of the species and a study of their pollen. Phyto Keys. 2016; 60: 49–126.
2.   Isawumi MA. Infrageneric classification of Vernonia (Vernonieae: Compositae) in West Africa. In Hind DJN, Beentje HJ (Editor), Compositae: systematics. Proceedings of the International Compositae Conference. Royal Botanic Gardens, Kew, London, UK. 1996; pp. 531-544.
3.   Robinson H. Generic and subtribal classification of American Vernonieae. Smithsonian Contributions to Botany. 1999; 89: 1–116.
4.   Robinson H. The status of generic and subtribal revisions in the Vernonieae. In Hind DJN, Beentje HJ (Editor), Compositae: systematics. Proceedings of the International Compositae Conference. Royal Botanic Gardens, Kew, London, UK. 1996; pp. 511-529.
5.   Robinson H. Tribe Vernonieae Cass. In Kadereit JW, Jeffrey C (Editor), The families and genera of vascular plants: Flowering plants: Eudicots, Asterales. Springer, Berlin, Germany. 2007; pp. 149-174.
6.   Isawumi MA. The status of generic revision in the African Vernonieae (Asteraceae). Compositae Newsletter. 2008; 46: 27-48.
7.   Jeffrey C. The Vernonieae in East Tropical Africa: Notes on Compositae. Kew Bulletin. 1988; 43(2): 195-277.
8.   Pope GV. Compositae. In Pope GV (Editor), Flora Zambesiaca: Mozambique, Malawi, Zambia, Zimbabwe and Botswana vol. 6 (1). Royal Botanic Gardens, Kew, London, UK. 1992; pp. 1–264.
9.   Germishuizen G, Meyer N.L. Plants of southern Africa: An annotated checklist. Strelitzia 14, National Botanical Institute, Pretoria, South Africa; 2003.
10.   Herman PPJ, Swelankomo N. Asteraceae: Vernonia (tribe Vernonieae) and related genera in southern Africa: Updates and corrections. Bothalia. 2011; 41(1): 176-178.
11.   Nwakanma NMC, Adekoya KO, Kadiri AB, Oboh BO. Leaf epidermal features in 14 species of Vernonia. Egyptian Academic Journal of Biological Sciences. 2018; 9(1): 59-73.
12.   Aworinde DO, Ogundairo BO, Erinoso SM. Comparative leaf architectural studies of some Vernonia Schreb (Asteraceae) in Nigeria. Current Botany. 2013; 4(3): 43-47.
13.   Chinwe UA. Anatomical studies of the midrib, petiole and epidermal strip of some Vernonia species, from Nigeria. International Journal of Botany 2020. 16: 9-19.
14.   Morris B. Chewa medical botany: A study of herbalism in southern Malawi. International African Institute, Lit Verlag, Hamburg, Germany; 1996.
15.   Heath A, Heath R. Field guide to the plants of northern Botswana including the Okavango Delta. Kew Publishing, Royal Botanic Gardens, Kew, London, UK; 2009.
16.   Figueiredo E, Smith GF. Plants of Angola. Strelitzia 22, South African National Biodiversity Institute, Pretoria, South Africa, 2008.
17.   Agnew ADQ, Agnew S. Upland Kenya wild flowers. East Africa Natural History Society, Nairobi, Kenya; 1994.
18.   Balsinhas AA. The weeds of abandoned cotton fields in Mozambique. Bothalia. 1983; 14: 971-975.
19.   Randall RP. A global compendium of weeds. Western Australia, Perth, Australia; 2017.
20.   Wentzel J, Van Ginkel CE. Distribution, use and ecological roles of the medicinal plants confined to freshwater ecosystems in South Africa. Water Research Commission, Pretoria, South Africa; 2012.
21.   Johannsmeier MF. Bee plants of South Africa: Sources of nectar, pollen and honeydew and propolis for honeybees. Strelitzia 37. South African National Botanical Institute, Pretoria, South Africa; 2016.
22.   Hilonga S, Otieno JN, Ghorbani A, Pereus D, Kocyan A, de Boer H. Trade of wild-harvested medicinal plant species in local markets of Tanzania and its implications for conservation. South African Journal of Botany. 2019; 122: 214–224.
23.   Oben JE. Plant extract mixtures and their uses. 2007. US 7175859B1, issued February 13, 2007.
24.   Gelfand M, Drummond RB, Mavi S, Ndemera B. The traditional medical practitioner in Zimbabwe: His principles of practice and pharmacopoeia. Mambo Press, Gweru, Zimbabwe; 1985.
25.   Maroyi A. A review of medicinal uses, phytochemistry and biological activities of Boscia angustifolia. Journal of Pharmaceutical Science and Research. 2019; 11: 3420-3428.
26.   Ngowi NJ. Ethnobotanical study of medicinal plants in Kondoa eroded area of central Tanzania. International Journal of Sciences: Basic and Applied Research. 2015; 21(1): 223-233.
27.   Sewani-Rusike CR. Plants of Zimbabwe used as anti-fertility agents. African Journal of Traditional Complementary and Alternative Medicine. 2010; 7(3): 253–257.
28.   Chhabra SC, Mahunnah RLA, Mshiu EN. Plants used in traditional medicine in Eastern Tanzania. II angiosperms (Capparidaceae-Ebenaceae). Journal of Ethnopharmacology. 1989; 25(3): 339–359.
29.   Burkill HM. The useful plants of West Tropical Africa Royal Botanic Gardens, Kew, London, UK; 1985.
30.   Toyang NJ, Verpoorte R. A review of the medicinal potentials of plants of the genus Vernonia (Asteraceae). Journal of Ethnopharmacology. 2013; 146: 681–723.
31.   Long C. Swaziland’s Flora-Siswati names and uses; 2005. Available from: http://www.sntc.org. sz/flora/clusagelist.asp?uid=2andpg=47S.
32.   Amusan OOG, Sukati NA, Dlamini PS, Sibandze FG. Some Swazi phytomedicines and their constituents. African Journal of Biotechnology. 2007; 6(3): 267-272.
33.   Nole T, Tsambang DWL, Ndikum VN, Tsambang FSC, Donfack D. Diabetes and arterial hypertension resorts of treatments and plants used for their treatments in three phytogeographic areas of Cameroon. International Journal of Traditional and Complementary Medicine. 2016; 1(4): 45-59.
34.   Tsabang N, Ngah N, Estella FT, Agbor GA. Herbal medicine and treatment of diabetes in Africa: Case study in Cameroon. Diabetes Case Reports. 2016; 1: 112.
35.   Tsabang N, Tsambang LWD, Yedjou CG, Tchounwou PB. Socio-cultural contribution to medicinal plants assessment and sustainable development: Case of antidiabetic and antihypertensive plants in Cameroon. Global Drugs and Therapeutics, 2017; 2(1): 1-6.
36.   Omale JM, Mutai P, Njogu P, Mukungu N, Mwangi J, Odongo E. Ethnobotanical survey of medicinal plants used in Emuhaya Subcounty, Vihiga County in Western Kenya. Applied Medical Research. 2020; 7(1): 6–25.
37.   Hedberg I, Staugård F. Traditional medicine in Botswana: Traditional medicinal plants. Ipelegeng Publishers, Gaborone, Botswana; 1989.
38.   Williamson J. Useful plants of Malawi. University of Malawi, Zomba, Malawi; 1975.
39.   Morris B. Medicinal plants of Malawi. University of London, London, UK; 1991.
40.   Johns T, Faubert GM, Kokwaro JO, Mahunnah RLA, Kimanani EK. Anti-giardial activity of gastrointestinal remedies of the Luo of East Africa. Journal of Ethnopharmacology. 1995; 46(1): 17-23.
41.   Ngonda F, Magombo Z, Mpeketula P, Mwatseteza J. Evaluation of Malawian Vernonia glabra (Steetz) Vatke leaf and Securidaca longepedunculata (Fresen) root extracts for antimicrobial activities. Journal of Applied Pharmaceutical Science. 2012; 2(11): 26–33.
42.   Kitonde CK, Fidahusein DS, Lukhoba CW. Antimicrobial activity and phytochemical study of Vernonia glabra (Steetz) Olive. and Hiern in Kenya. African Journal of Traditional Complementary and Alternative Medicine. 2013; 10(1): 149–157.
43.   Kitonde CK, Fidahusein DS, Lukhoba CW, Jumba MM. Phytochemistry and utilization of Vernonia glabra (Steetz) Oliv. and Hiern. in management of food spoilage and poisoning pathogens, in Kenya. European International Journal of Science and Technology. 2014; 3(1): 65-72.
44.   Ngonda F. Investigation of heavy metals contents in Malawian Vernonia glabra (Steetz) Vatke leaves, Trichodesma zeylanicum roots and Securidaca longepedunculata (Fresen) roots. American Journal of Pharmacology and Pharmacotherapeutics. 2014; 1(1): 16-21.
45.   Maregesi SM, Mwakalukwa R. Ethnopharmacological study on medicinal plants used to treat infectious diseases in the Rungwe District, Tanzania. International Journal of Medicinal Plants and Natural Products. 2015; 1(3): 15-23.
46.   Mkhize Z. Structure and synthesis of bioactive natural products. PhD Thesis. University of KwaZulu-Natal, Pietermaritzburg, South Africa; 2015.
47.   Sobrinho ACN, de Souza EB, Fontenelle ROS. A review on antimicrobial potential of species of the genus Vernonia (Asteraceae). Journal of Medicinal Plants Research. 2015; 9(31): 838-850.
48.   Kitonde CK, Fidahusein DS, Lukhoba CW, Wagacha JM, Klittich C, Don H, Fotso S, Graupner P, Slanec T. Effect of vernodalol, a sesquiterpene lactone, on economically important agricultural fungi. International Journal of Innovative Science and Research Technology. 2019; 4(3): 685-694.
49.   Ruffo CK. A survey of medicinal plants in Tabora region, Tanzania In: Traditional Medicinal Plants, Dar es Salaam University Press, Dar es Salaam, Tanzania; 1991.
50.   Nole T, Lionel TDW, Cedrix TFS, Gabriel AA. Ethnomedical and ethnopharmacological study of plants used for potential treatments of diabetes and arterial hypertension by indigenous people in three phytogeographic regions of Cameroon. Diabetes Case Reports. 2016; 1: 110.
51.   Kokwaro JO. Medicinal plants of East Africa. University of Nairobi Press, Nairobi, Kenya; 2009
52.   Nondo RSO, Zofou D, Moshi MJ, Erasto P, Wanji S, Ngemenya MN, Titanji VPK, Kidukuli AW, Masimba PJ. Ethnobotanical survey and in vitro antiplasmodial activity of medicinal plants used to treat malaria in Kagera and Lindi regions, Tanzania. Journal of Medicinal Plants Research. 2015; 9(6): 179-192.
53.   Kaingu CK, Oduma JA, Kanui TI. Practices of traditional birth attendants in Machakos District, Kenya. Journal of Ethnopharmacology. 2011; 137: 495–502.
54.   Msonthi JD. Herbs of medicinal value in Malawi: A potential for drug formulation. Proceedings of a National Forestry Research Symposium; 1987, pp. 146-161.
55.   Owuor BO, Kisangau DP. Kenyan medicinal plants used as antivenin: a comparison of plant usage. Journal of Ethnobiology and Ethnomedicine. 2006; 2: 7.
56.   Félix-Silva J, Silva-Junior AA, Zucolotto SM, Fernandes-Pedrosa MF. Medicinal plants for the treatment of local tissue damage induced by snake venoms: An overview from traditional use to pharmacological evidence. Evidence-Based Complementary and Alternative Medicine 2017, Article ID 5748256.
57.   Bohlmann F, Goren NA, Jakupovic J. Hirsutinolides from South African Vernonia species. Phytochemistry. 1983; 22(5): 1159-I162.
58.   Jakupovic J, Baruah RN, Chau TTV, Bohlmann F, Msonthi JD, Schmeda-Hirschmann G. New vernolepin derivatives from Vernonia glabra and glaucolides from Vernonia scorpioides. Ptanta Medica. 1985, 378-380.
59.   Kitonde C, Fidahusein DS, Lukhoba CW, Wagacha JM, Klittich C, Hahn D, Fotso S, Graupner P, Slanec T, Xiong Q. In vitro studies of 3-O-methylquercetin against phytopathogenic fungi of major cereals. Journal of Agricultural Science and Practice. 2019; 4(4): 102-112.
60.   Bhowmik D, Pankaj C, Tripathi KK, Chandira MR, Kumar KPS. Zingiber officinale the herbal and traditional medicine and its therapeutically importance. Research Journal of Pharmacognosy and Phytochemistry. 2010; 2(2): 102-110.
61.   Singh UP, Parthasarathy R. Comparative pharmacognostical, preliminary phytochemical and acute toxicological evaluation of Blumea lacera var lacera and Blumea eriantha DC. Research Journal of Pharmacy and Technology. 2012; 5(6): 834-841.
62.   Sahu L, Roy A, Satapathy T. A phytopharmacological review on Lawsonia inermis L. Research Journal of Science and Technology. 2012; 4(3): 93-107.
63.   Mukhtar HM, Singh M, Vashishth D, Singh S, Kaur H. Standardization of the dried aerial parts of Bidens pilosa. Research Journal of Pharmacognosy and Phytochemistry. 2013; 5(2): 84-86.
64.   Mital NM, Desai TR. In vitro anti-inflammatory and anti-Arthritic activities of fruits of Vernonia anthelmintica Willd. (Asteraceae). Asian Journal of Pharmaceutical Research. 4(4): 186-188.
65.   Bhatt DY, Pandya SS. Pharmacognostic and preliminary phytochemical studies on the leaf of Beta vulgaris Linn. (Chenopodiaceae). Research Journal of Pharmacognosy and Phytochemistry. 2015; 7(3): 163-166.
66.   Tiwari VJ. Validity of ethnopharmacological uses of Vicoa indica (L.) DC., family – Asteraceae. Research Journal of Pharmacognosy and Phytochemistry. 2018; 10(3): 207-210.
67.   Gopalasatheeskumar K, Ariharasiva KG, Sengottuvel T, Sanish DV, Srividhya V. Quantification of total phenolic and flavonoid content in leaves of Cucumis melo var agrestis using UV- spectrophotometer. Asian Journal of Research Chemistry. 2019; 12(6): 335-337.
68.   Taheri F, Abbaszadeh S, Valibeik A, Sattari E, Gholami E. The most important natural antioxidants and native herbs of Iran used in the nervous system as pre-anesthetics. Research Journal of Pharmacy and Technology. 2019; 12(3): 1453-1456.
69.   Rohini KC, Rajesh CY. A review on phytopharmacological profile of traditionally used medicinal plant Parkia biglandulosa (Mimosaceae). Asian Journal of Pharmaceutical Research. 2020; 10(1): 34-38.
70.   Gundidza M. Screening of extracts from Zimbabwean higher plants II: antifungal properties. Fitoterapia. 1986; 57: 111-114.
71.   Achola KJ, Mwangi JW, Munenge RW, Mwaura AM. Pharmacological activities of Vernonia glabra. Pharmaceutical Biology. 1996; 34: 141–144.