Synthesis and Antibacterial Evaluation of 1,3-Benzoxazepine-1,5-diones bearing Benzothiazole Moiety

Zeid Hassan Abood; Zahraa Kadum Chafcheer; Husham Attallah Suhail

doi:10.52711/0974-360X.2021.00336

Research Journal of Pharmacy and Technology

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0974-360X (Online)
0974-3618 (Print)

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Synthesis and Antibacterial Evaluation of 1,3-Benzoxazepine-1,5-diones bearing Benzothiazole Moiety

Author(s): Zeid Hassan Abood, Zahraa Kadum Chafcheer, Husham Attallah Suhail

Email(s): husham.a@uokerbala.edu.iq

DOI: 10.52711/0974-360X.2021.00336

Address: Zeid Hassan Abood*, Zahraa Kadum Chafcheer, Husham Attallah Suhail
Chemistry Department, College of Science, University of Kerbala, Kerbala-Iraq.
*Corresponding Author

Published In: Volume - 14, Issue - 4, Year - 2021

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ABSTRACT:
Azo-aldehyde derivative (2) was prepared through reaction of 2-hydroxybenzaldehyde with diazonium ion generated from 2-aminobenzothiazole (1). The producing aldehyde (2) was then treated with some anilines consisting (4-nitroaniline, 3-nitroaniline, 4-aminophenol, 4-methoxyaniline, 4-bromoaniline, 4-chloroaniline and 2,4-dichloroaniline) by (MW) method to give seven Schiff bases (3a-g). Cyloaddition reactions of Schiff bases (3a-g) and phthalic anhydride utilizing (MW) means in dry benzene yielded seven new 1,3-benzoxazepine-1,5-diones (4a-g) carrying the unit of benzothiazole. Determination of verves of final benoxazepines athwart bacteria done on Staphylococcus aurous (Gram-positive) and Escherichia coli (Gram-negative). The outputs showed that all benzoxazepine compounds exhibited greater activity to standard antibiotic (gentamycin) athwart Staphylococcus aurous. Moreover, the benzoxazepines (4a, 4b, 4c, 4d, 4e and 4g) appeared best activity athwart Escherichia coli comparably with that of standard antibiotic.

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Cite this article:
Zeid Hassan Abood, Zahraa Kadum Chafcheer, Husham Attallah Suhail. Synthesis and Antibacterial Evaluation of 1,3-Benzoxazepine-1,5-diones bearing Benzothiazole Moiety. Research Journal of Pharmacy and Technology. 2021; 14(4):1905-9. doi: 10.52711/0974-360X.2021.00336

Cite(Electronic):
Zeid Hassan Abood, Zahraa Kadum Chafcheer, Husham Attallah Suhail. Synthesis and Antibacterial Evaluation of 1,3-Benzoxazepine-1,5-diones bearing Benzothiazole Moiety. Research Journal of Pharmacy and Technology. 2021; 14(4):1905-9. doi: 10.52711/0974-360X.2021.00336 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-4-12

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