ABSTRACT:
A newly, simple and precise Spectrophotometric methods were improved for the determination of Ceftriaxone (XONE) in pure and pharmaceutical formulations which Involved the reaction of FeCl3/(FeNO3)3 with (XONE) to yield a dark-blue greenish dissolved composite which has maximum absorbance at 780nm. This process was sensitive, precise and accurate where the limit of detection was (0.08µg/ml) and the RSD% was 0.65% and Recovery was 95%. Various chemical and physical conditions that affected the reaction have been elaborate. The calibration curve was straight within the concentration range 0.5-12µg/mL. Stability constant, Molar absorptivity and Sandell’s sensitivity were (5.1x109, 121 and 0.0045) respectively The design procedure was appropriate efficiently for the estimate of XONE and the results possess were favorably comparison with those addicted by a reference method of British Pharmacopeia, and there was no important difference between the obtained results, regarding accuracy and precision at the 95% confidence level.
Cite this article:
Assaf H. Tawfeeq, Bushra B. Qassim. New Spectrophotometric procedure for Assaying Ceftriaxone. Research Journal of Pharmacy and Technology. 2021; 14(4):1928-2. doi: 10.52711/0974-360X.2021.00341
Cite(Electronic):
Assaf H. Tawfeeq, Bushra B. Qassim. New Spectrophotometric procedure for Assaying Ceftriaxone. Research Journal of Pharmacy and Technology. 2021; 14(4):1928-2. doi: 10.52711/0974-360X.2021.00341 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-4-17
REFERENCES:
1. Warren Lowman, Naseema Aithma, Johan F Coetzee, Adriano G Dusè, Mervyn Mer. Comparative MIC evaluation of a generic ceftriaxone by broth microdilution on clinically relevant isolates from an academic hospital complex in South Africa. South African Medical Journal.2012;102(2): 102-103
2. Gamal Abdelaziz Hussein Gouda, Gomaa Abdelgawad Mohammed Ali. Potentiometric Study of Rhenium(V) Complex Formation with Azathioprine and Ceftriaxone. Malaysian Journal of Analytical Sciences. 2017; 21(6): 1266 – 1275
3. Mohd Yaqub Khan, Maryada Roy, Raj Kumar Rawal, Umesh Kumar Bansal. A Review- Ceftriaxone for Life. Asian Journal Pharm Researchs. 2017; 7 (1): 35-48
4. Abu Tariq, Masoom Raza Siddiqui, Jitendra Kumar, Dinesh Reddy, Prithvi Singh Negi,Manu Chaudhary, Sanjay Mohan Srivastava, Raj Kumar Singh . Development and validation of high performance liquid chromatographic method for the simultaneous determination of ceftriaxone and vancomycin in pharmaceutical formulations and biological samples. Science Asia. 2010; 36: 297–304
5. British Pharmacopoeia, The Stationary Office Ltd.; London. 2009; vol (I&II): pp 1-5
6. M Jambulingam, SA Thangathurai, D Kamalakannan, S Punitha, TR Rincy, S Santhi, G Surya, M Vasanthi, SJ Subarla. A Simple spectrophotometric estimation of ceftriaxone sodium in bulk and sterile formulation. PharmaTutor. 2015; 3(9): 48-52
7. A.R. Guru Prasad, V.S. Rao. Polarographic determination of certain cephalosporins in pharmaceutical preparations. Research in Pharmaceutical Sciences. 2010; 5(1): 57-63
8. Elgendy Kh., Turkey A., Fadel S. Automatic Potentiometeric Determination of Some Third Generation Cephalosporin's Antibiotics. World Journal of Pharmacy and Pharmaceutical Sciences. 2018; 7 (12): 296-307
9. Jasmin Shah, M. Rasul Jan, Sultan Shah, M. Naeem Khan. Development and Validation of HPLC Method for Simultaneous Determination of Ceftriaxone and Cefaclor in Commercial Formulations and Biological Samples. Journal of the Mexican Chemical Society. 2013; 57(4), 314-320
10. Deyi zhang, yongjun ma, min zhou, li li, hui chen. determination of ceftriaxone sodium in pharmaceutical formulations by flow injection analysis with acid potassium permanganate chemiluminescence detection. The japan society for analytical chemistry. 2006; 22: 183-186
11. Naser Samadi , Saeedeh Narimani. An ultrasensitive and selective method for the determination of Ceftriaxone using cysteine capped cadmium sulfide fluorescence quenched quantum dots as fluorescence probes. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2016;163: 8–12
12. Laleh Enayati Ahangar, Karim Movassaghia, Fahimeh Bahramib, Mehran Enayatib, Angelo Chianesec. Determination of Drugs in Biological Sample by Using Modified Magnetic Nanoparticles and HPLC. Chemical Engineering Transactions. 2014; 38: 391-396
13. V. V. Khasanov, E. G. Sokolovich, K. A. Dychko. Determination of Ceftriaxone in Blood and Tissues Using Ion-Exchange Chromatography. Pharmaceutical Chemistry Journal. 2006; 40(2): 109-110
14. Amber Solangi, Saima Memon, Arfana Mallah, Najma Memon, Muhammad Yar Khuhawar, Muhammad Iqbal Bhanger. Determination of ceftriaxone, ceftizoxime, paracetamol, and diclofenac sodium by capillary zone electrophoresis in pharmaceutical formulations and in human blood serum. Turkish Journal of Chemistry. 2010; 34: 921-933
15. ICH Harmonized Tripartite Guideline, Validation of Analytical Procedures: Text and Methodology Q2(R1). 2005; pp 11-13