Author(s):
Tulsidas Nimbekar, Ashish Jain, Pradeep Kumar Mohanty
Email(s):
tnimbekar@gmail.com
DOI:
10.52711/0974-360X.2021.00359
Address:
Tulsidas Nimbekar1*, Ashish Jain2, Pradeep Kumar Mohanty2
1Bajiraoji Karanjekar College of Pharmacy, Sakoli, Dist.- Bhandara, Maharashtra 441802, India.
2School of Pharmacy, Department of Pharmaceutical Sciences, LNCT University, Bhopal, M.P.
*Corresponding Author
Published In:
Volume - 14,
Issue - 4,
Year - 2021
ABSTRACT:
The present scientific investigation deals with the extraction of some Indian medicinal plants include, Manilkara hexandra Roxb. stem bark (Sapotaceae), Strychnous potatorum Linn. dried seeds (Loganiaceae), Salacia reticulata Wight. stem bark (Celastraceae) and identification of chemical constituents by using preliminary phytochemical tests. The extracts were screened for their potential in-vitro anti-diabetic studies so as to ensure the biological potency of the plant. The study also includes qualitative screening of the phytonutrients, Free radical scavenging activity by DPPH assay method and assessment of total antioxidant activity by phosphor-molybdate assay method were evaluated. From the study we revealed that the all plants contain various classes of secondary metabolites and also possess a moderate anti-diabetic activity it terms of alpha amylase inhibition.
Cite this article:
Tulsidas Nimbekar, Ashish Jain, Pradeep Kumar Mohanty. Phytochemical screening and In-Vitro Antidiabetic Activity of Extracts of some Indian Medicinal Plants. Research Journal of Pharmacy and Technology. 2021; 14(4):2026-0. doi: 10.52711/0974-360X.2021.00359
Cite(Electronic):
Tulsidas Nimbekar, Ashish Jain, Pradeep Kumar Mohanty. Phytochemical screening and In-Vitro Antidiabetic Activity of Extracts of some Indian Medicinal Plants. Research Journal of Pharmacy and Technology. 2021; 14(4):2026-0. doi: 10.52711/0974-360X.2021.00359 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2021-14-4-35
REFERENCES:
1. WHO, (1999). Definition, Diagnosis and classification of Diabetes Mellitus and its complication, department of non-communicable Diseases Surveillance Geneve, Part 1 Diagnosis and Classification of Diabetes Mellitus: 2.
2. International Diabetes Federation. IDF Diabetes Atlas, 8th edn. Brussels, Belgium: International Diabetes Federation, 2017. http://www.diabetesatlas.org; last accessed on January 23, 2019.
3. NCD Risk Factor Collaboration (NCD-RisC). Worldwide Trends in Diabetes since 1980: A Pooled Analysis of 751 Population-Based Studies with 4•4 Million Participants. Lancet. 2016; 387(10027):1513–30.
4. Harding JL, Pavkov ME, Magliano DJ, Shaw JE, Gregg EW. Global trends in diabetes complications: a review of current evidence. Diabetologia (2019) 62:3–16.
5. Seshasai SR, Kaptoge S, Thompson A, et al. Emerging Risk Factors Collaboration. Diabetes mellitus, fasting glucose, and risk of cause-specific death. New England Journal of Medicine 2011; 364:829–841.
6. Rawshani A, Rawshani A, Franzén S, Eliasson B, Svensson A-M, Miftaraj M, McGuire DK, Sattar N, Rosengren A, Gudbjörnsdottir S. Mortality and Cardiovascular Disease in Type 1 and Type 2 Diabetes. N Engl J Med 2017; 376:1407-1418.
7. Krishnaiah D, Devi T, Bono A, Sarbatly R (2009). Studies on phytochemical constituents of six Malaysian medicinal plants. J. Med. Plants Res., 3(2): 67-72.
8. Houghton PJ, Raman A. Laboratory handbook for fractionation of natural extracts. Chapman and Hall, London, 1998, 32.
9. Brand-Williams W, Cuvelier ME, Berset C. Use of a free radical method to evaluate antioxidant activity. Lebenson Wiss Technol. 1995; 28:25–30.
10. Umamaheswari M, Chatterjee T K. In vitro antioxidant activities of the fractions of Coccinia grandis L. leaf extract. African J Trad Compl Altern Medicines. 2008; 5:61–73.
11. Jayasri MA, Radha A, Mathew TL. α-amylase and α-glucosidase inhibitory activity of Costuspictus D. Don in the management of diabetes. Journal of Herbal Medicine and Toxicology. 2009; 3(1):91-94.